Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 11/20 | 0.45 |
| ▸ | JAK2 | O60674 | 9/20 | 0.44 |
| ▸ | JAK1 | P23458 | 6/20 | 0.44 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.41 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068967 | 0.90 | KCNQ3 (0.43) | DHODHTYK2KCNQ3KCNQ2KCNE1 | |
| SCHEMBL4068770 | 0.83 | NPC1 (0.50) | DHODHMEN1KMT2AHPGD | |
| SCHEMBL4061473 | 0.80 | DHODH (0.49) | DHODHTYK2JAK2JAK1ABL1 | |
| SCHEMBL5934780 | 0.71 | P4HTM (0.53) | KCNQ3KCNQ2KCNE1KCNQ1MEN1 | |
| SCHEMBL4070581 | 0.71 | POLB (0.46) | TYK2JAK2JAK1ABL1SRC | |
| SCHEMBL4059298 | 0.71 | TYK2 (0.50) | TYK2JAK2JAK1ABL1SRC | |
| SCHEMBL4061697 | 0.70 | GRM8 (0.55) | TYK2JAK2JAK1 | |
| SCHEMBL11009109 | 0.70 | PTPN1 (0.49) | TYK2JAK2JAK1KCNQ3KCNQ2 | |
| SCHEMBL13133446 | 0.69 | KCNQ3 (0.53) | TYK2JAK2JAK1KCNQ3KCNQ2 | |
| SCHEMBL439071 | 0.69 | IL2 (0.50) | DHODHKCNQ3KCNQ2KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |