Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KCNQ3 | O43525 | 4/20 | 0.39 |
| ▸ | KCNQ2 | O43526 | 4/20 | 0.39 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.39 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.39 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070581 | 0.92 | POLB (0.46) | TYK2POLBABL1SRCNPSR1 | |
| SCHEMBL4068779 | 0.87 | NPC1 (0.51) | TYK2GRM4RAB9A | |
| SCHEMBL4063151 | 0.72 | P4HTM (0.43) | TYK2ABL1SRCPTPN2PTPN1 | |
| SCHEMBL4068967 | 0.72 | KCNQ3 (0.43) | TYK2POLBABL1SRCKCNQ3 | |
| SCHEMBL4247327 | 0.70 | BRAF (0.45) | TYK2ABL1SRCKCNQ3KCNQ2 | |
| SCHEMBL4061473 | 0.70 | DHODH (0.49) | TYK2POLBABL1SRCITGB1 | |
| SCHEMBL4061085 | 0.70 | POLB (0.50) | TYK2POLBABL1SRCKCNQ3 | |
| SCHEMBL4062046 | 0.68 | MAPT (0.54) | POLBNPSR1KCNQ3KCNQ2KMT2A | |
| SCHEMBL14667046 | 0.67 | PTGS2 (0.49) | TYK2POLBKMT2APTGS2RAB9A | |
| SCHEMBL4061677 | 0.67 | HTR2C (0.53) | POLBKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |