Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.43 |
| ▸ | F2R | P25116 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 4/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061473 | 0.89 | DHODH (0.49) | ABL1SRCDHODHHPGDTYK2 | |
| SCHEMBL4072365 | 0.86 | KMT2A (0.51) | ABL1SRCDHODHMAPTMEN1 | |
| SCHEMBL4063742 | 0.81 | DHODH (0.53) | DHODHMEN1LMNAKMT2ATP53 | |
| SCHEMBL4068987 | 0.81 | P4HTM (0.58) | P4HTMABL1DHODHPTPN1MAPT | |
| SCHEMBL8230263 | 0.80 | IL2 (0.50) | ABL1SRCDHODHMEN1LMNA | |
| SCHEMBL4068967 | 0.79 | KCNQ3 (0.43) | P4HTMF2RABL1SRCDHODH | |
| SCHEMBL4065422 | 0.78 | HPGD (0.50) | P4HTMF2RABL1SRCMAPT | |
| SCHEMBL4060843 | 0.77 | HTR2C (0.50) | MEN1LMNAKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL439071 | 0.75 | IL2 (0.50) | DHODHMAPTMEN1LMNAKMT2A | |
| SCHEMBL12155575 | 0.74 | NPC1 (0.55) | WNT3ALMNATP53HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |