Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | DHODH | Q02127 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 7/20 | 0.53 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PTPRC | P08575 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | CTSS | P25774 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072365 | 0.90 | KMT2A (0.51) | MAPTDHODHRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4063742 | 0.86 | DHODH (0.53) | LMNADHODHRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL12155531 | 0.82 | NPC1 (0.60) | P4HTMLMNAMAPTRAB9ANPC1 | |
| SCHEMBL4063151 | 0.81 | P4HTM (0.43) | P4HTMLMNAMAPTDHODHSMN1; SMN2 | |
| SCHEMBL4059192 | 0.80 | NPC1 (0.60) | P4HTMLMNAMAPTDHODHRAB9A | |
| SCHEMBL4061473 | 0.78 | DHODH (0.49) | DHODHRAB9AHPGDABL1 | |
| SCHEMBL8230263 | 0.78 | IL2 (0.50) | LMNADHODHRAB9ANPC1MEN1 | |
| SCHEMBL13581604 | 0.76 | MEN1 (0.83) | LMNAMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL439071 | 0.74 | IL2 (0.50) | LMNAMAPTDHODHRAB9ANPC1 | |
| SCHEMBL27972423 | 0.72 | MEN1 (0.70) | LMNAMAPTRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |