Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 3/20 | 0.47 |
| ▸ | KCNQ3 | O43525 | 5/20 | 0.46 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.46 |
| ▸ | KCNE1 | P15382 | 4/20 | 0.46 |
| ▸ | KCNQ1 | P51787 | 4/20 | 0.46 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.46 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.46 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.46 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13133446 | 0.90 | KCNQ3 (0.53) | IL2KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL8230263 | 0.89 | IL2 (0.50) | IL2MEN1KMT2ADHODHKCNQ3 | |
| SCHEMBL15395780 | 0.87 | MAPK7 (0.53) | IL2MEN1KMT2AMAPK7DHODH | |
| SCHEMBL454031 | 0.85 | IL2 (0.71) | IL2KCNQ3KCNQ2KCNE1KCNQ1 | |
| SCHEMBL15395892 | 0.84 | STIM1 (0.63) | IL2MEN1KMT2ASTIM1ORAI1 | |
| SCHEMBL16363192 | 0.82 | IL2 (0.71) | IL2MEN1KMT2ASTIM1ORAI1 | |
| SCHEMBL15395974 | 0.81 | L3MBTL1 (0.49) | IL2MEN1KMT2ASTIM1ORAI1 | |
| SCHEMBL13133468 | 0.81 | IL2 (0.52) | IL2KMT2ASTIM1ORAI1ORAI2 | |
| SCHEMBL2813597 | 0.80 | IL2 (0.48) | IL2STIM1ORAI1ORAI2LMNA | |
| SCHEMBL2812935 | 0.80 | IL2 (0.54) | IL2LMNARAB9ANPC1CRACR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140187586-A1 | PYRIDYLPHENYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2014-07-03 | — | — | US | disclosed |
| US-20120064121-A1 | PYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (MA) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120064121-A1 | PYRIDINE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | IL5, CXCR3, TSLP | IL2 24/4885MEN1 4480/4885KMT2A 2484/4885 |
| US-20140187586-A1 | PYRIDYLPHENYL COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | CCR1, CXCR3, NLRP1 | IL2 77/4885MEN1 4056/4885KMT2A 4055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.