Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | BLK | P51451 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.49 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | PTGES | O14684 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068987 | 0.90 | P4HTM (0.58) | KMT2AMEN1SMN1; SMN2HPGDABL1 | |
| SCHEMBL4063742 | 0.90 | DHODH (0.53) | KMT2AMEN1SMN1; SMN2HPGDKCNK3 | |
| SCHEMBL4063151 | 0.86 | P4HTM (0.43) | KMT2AMEN1SMN1; SMN2HPGDABL1 | |
| SCHEMBL4061473 | 0.81 | DHODH (0.49) | HPGDABL1SRCPOLBTYK2 | |
| SCHEMBL12155546 | 0.81 | NPC1 (0.64) | KMT2AMEN1L3MBTL1BLKSMN1; SMN2 | |
| SCHEMBL4068770 | 0.80 | NPC1 (0.50) | KMT2AMEN1L3MBTL1BLKSMN1; SMN2 | |
| SCHEMBL4059473 | 0.79 | BLK (0.52) | KMT2AMEN1L3MBTL1BLKSMN1; SMN2 | |
| SCHEMBL4063740 | 0.78 | HTR2C (0.54) | KMT2AL3MBTL1BLKSMN1; SMN2CYP1A2 | |
| SCHEMBL25143492 | 0.77 | HPGD (0.63) | L3MBTL1BLKSMN1; SMN2CYP1A2HPGD | |
| SCHEMBL31665584 | 0.77 | HPGD (0.63) | L3MBTL1BLKSMN1; SMN2CYP1A2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |