Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RARB | P10826 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2454478 | 0.94 | ALPL (0.50) | ALPLARPLA2G2ATSHRMAOA | |
| SCHEMBL2455403 | 0.92 | TP53 (0.51) | PLA2G2ATP53TSHRPLA2G4BPTPN11 | |
| SCHEMBL10986249 | 0.86 | PLA2G2A (0.56) | PLA2G2ATP53TSHRPLA2G4BPTPN11 | |
| SCHEMBL15956090 | 0.83 | TSHR (0.50) | TP53TSHRNPC1LMNACYP1A2 | |
| SCHEMBL4078541 | 0.83 | TP53 (0.43) | PLA2G2ATP53TSHRPLA2G4BNR1H4 | |
| SCHEMBL21623015 | 0.81 | AR (0.49) | ARTP53NPC1LMNAMAPT | |
| SCHEMBL10098352 | 0.80 | KDM4E (0.47) | MAOAMAPT | |
| SCHEMBL22476690 | 0.78 | PLA2G2A (0.54) | ALPLPLA2G2ATP53TSHRPLA2G4B | |
| SCHEMBL27639521 | 0.78 | KDM4E (0.52) | ALPLTP53TSHRPLA2G4BNPC1 | |
| SCHEMBL4134527 | 0.77 | KDM4E (0.45) | LMNAMAPTRARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010535-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | disclosed |
| WO-2007120098-A1 | THIOXANTHINE DERIVATIVES AND THEIR USE AS INHIBITORS OF MPO | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | disclosed |