Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.48 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4058761 | 0.89 | HTR2C (0.48) | HTR2CGAAPKMKCNK3KCNK9 | |
| SCHEMBL4058778 | 0.88 | GAA (0.56) | HTR2CGAAHTTPKML3MBTL1 | |
| SCHEMBL4073222 | 0.83 | HTR2C (0.71) | HTR2CGAAHTTNPC1RAB9A | |
| SCHEMBL8143964 | 0.82 | PKM (0.65) | HTR2CGAAHTTPKML3MBTL1 | |
| SCHEMBL2663101 | 0.82 | KMT2A (0.53) | HTR2CGAAPKMKMT2A | |
| SCHEMBL4061474 | 0.82 | HTR2C (0.58) | HTR2CGAAHTTPKML3MBTL1 | |
| SCHEMBL4063740 | 0.82 | HTR2C (0.54) | HTR2CGAAHTTPKML3MBTL1 | |
| SCHEMBL4061558 | 0.81 | HTR2C (0.50) | HTR2CGAAHTTKCNK3KCNK9 | |
| SCHEMBL4060261 | 0.81 | POLB (0.48) | HTR2CKCNK3KCNK9SMN1; SMN2POLB | |
| SCHEMBL4062244 | 0.80 | PNLIP (0.60) | HTR2CGAAHTTKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |