Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.54 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4063941 | 0.88 | S1PR1 (0.51) | SMN1; SMN2LMNAS1PR1HPGDRAB9A | |
| SCHEMBL4068903 | 0.88 | NPC1 (0.51) | SMN1; SMN2GAAS1PR1HPGDMEN1 | |
| SCHEMBL4072949 | 0.80 | S1PR1 (0.49) | LMNATP53S1PR1HPGDTRPV1 | |
| SCHEMBL4060466 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNATSHRTP53GAA | |
| SCHEMBL10075394 | 0.76 | JAK2 (0.66) | — | |
| SCHEMBL845817 | 0.74 | TRPV1 (0.74) | SMN1; SMN2TP53RAB9ANPC1TRPV1 | |
| SCHEMBL846037 | 0.73 | TRPV1 (0.80) | SMN1; SMN2RAB9ANPC1ALDH1A1TRPV1 | |
| SCHEMBL27544662 | 0.72 | GRM4 (0.62) | SMN1; SMN2LMNATSHRTP53GAA | |
| SCHEMBL27889255 | 0.71 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNATSHRTP53GAA | |
| SCHEMBL27905928 | 0.71 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNATSHRTP53GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |