Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 8/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 4/20 | 0.42 |
| ▸ | JAK3 | P52333 | 4/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.42 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068903 | 0.88 | NPC1 (0.51) | S1PR1PIK3CATRPV1HPGDMTOR | |
| SCHEMBL4063941 | 0.88 | S1PR1 (0.51) | S1PR1TRPV1MAPK7HPGDLCK | |
| SCHEMBL4069506 | 0.80 | SMN1; SMN2 (0.54) | S1PR1TRPV1MAPK7HPGDLMNA | |
| SCHEMBL4064073 | 0.78 | S1PR1 (0.50) | S1PR1TRPV1TP53 | |
| SCHEMBL4061052 | 0.76 | NAMPT (0.49) | S1PR1PIK3CAMAPK7MTOR | |
| SCHEMBL17607243 | 0.73 | MAPK7 (0.47) | S1PR1PIK3CATRPV1MAPK7MTOR | |
| SCHEMBL846037 | 0.72 | TRPV1 (0.80) | TRPV1 | |
| SCHEMBL13229353 | 0.70 | POLB (0.53) | MAPK7LMNA | |
| SCHEMBL5483909 | 0.70 | SMN1; SMN2 (0.53) | LMNATP53 | |
| SCHEMBL4063151 | 0.69 | P4HTM (0.43) | HPGDRXFP1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |