Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.48 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | MTOR | P42345 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069506 | 0.88 | SMN1; SMN2 (0.54) | NPC1L3MBTL1TRPV1S1PR1MEN1 | |
| SCHEMBL4072949 | 0.88 | S1PR1 (0.49) | TRPV1S1PR1PIK3CAMTORHPGD | |
| SCHEMBL4063941 | 0.80 | S1PR1 (0.51) | NPC1TRPV1S1PR1SMN1; SMN2RAB9A | |
| SCHEMBL4064076 | 0.78 | MEN1 (0.58) | NPC1L3MBTL1CYP1A2TRPV1S1PR1 | |
| SCHEMBL4063306 | 0.76 | L3MBTL1 (0.51) | NPC1L3MBTL1CYP1A2S1PR1CRACR2A | |
| SCHEMBL30010142 | 0.76 | TRPV1 (0.55) | NPC1L3MBTL1CYP1A2TRPV1SMN1; SMN2 | |
| SCHEMBL846037 | 0.74 | TRPV1 (0.80) | NPC1TRPV1SMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL25143492 | 0.74 | HPGD (0.63) | NPC1L3MBTL1CYP1A2SMN1; SMN2RAB9A | |
| SCHEMBL31665584 | 0.74 | HPGD (0.63) | NPC1L3MBTL1CYP1A2SMN1; SMN2RAB9A | |
| SCHEMBL4063294 | 0.73 | MEN1 (0.53) | NPC1L3MBTL1CYP1A2S1PR1CRACR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |