SCHEMBL406969

SCHEMBL406969

CC(OO)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.46
CYP3A4 P08684 1/20 0.46
CYP19A1 P11511 1/20 0.45
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
LMNA P02545 3/20 0.42
HTT P42858 2/20 0.42
TSHR P16473 3/20 0.42
L3MBTL1 Q9Y468 3/20 0.39
GALR3 O60755 1/20 0.39
ALOX5 P09917 2/20 0.39
VCAM1 P19320 1/20 0.38
ALDH1A1 P00352 3/20 0.38
GPR35 Q9HC97 1/20 0.38
HPGD P15428 1/20 0.38
ACHE P22303 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11787514 0.81 ALDH1A1 (0.50) CYP3A4MEN1KMT2ATSHRL3MBTL1
SCHEMBL4623730 0.79 SMN1; SMN2 (0.49) SMN1; SMN2CYP3A4CYP19A1MEN1KMT2A
SCHEMBL7590710 0.78 CYP19A1 (0.50) SMN1; SMN2CYP3A4CYP19A1MEN1KMT2A
SCHEMBL8250738 0.77 CYP19A1 (0.54) SMN1; SMN2CYP3A4CYP19A1MEN1KMT2A
SCHEMBL11027636 0.75 KMT2A (0.40) SMN1; SMN2CYP3A4CYP19A1MEN1KMT2A
SCHEMBL11027189 0.75 CYP3A4 (0.38) SMN1; SMN2CYP3A4CYP19A1MEN1KMT2A
Hydrogen Peroxide SCHEMBL11574430 0.74 KMT2A (0.47) SMN1; SMN2CYP3A4CYP19A1MEN1KMT2A
SCHEMBL5495729 0.74 CYP19A1 (0.50) SMN1; SMN2CYP3A4CYP19A1MEN1KMT2A
SCHEMBL11213892 0.74 CYP19A1 (0.50) SMN1; SMN2CYP3A4CYP19A1MEN1KMT2A
SCHEMBL7696997 0.74 CYP19A1 (0.50) SMN1; SMN2CYP3A4CYP19A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120064002-A1 Enantiomer-pure (4S,8S)- and (4R,8R)-4-p-Nitrobenzyl-8-methyl-3,6,9-triaza-3N,6N,9N-tricarboxymethyl-1,11-undecanedioic Acid and Derivatives Thereof, Process for their Production and Use for the Production of Pharmaceutical Agents LEHMANN LUTZ (DE) 2012-03-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120064002-A1 Enantiomer-pure (4S,8S)- and (4R,8R)-4-p-Nitrobenzyl-8-methyl-3,6,9-triaza-3N,6N,9N-tricarboxymethyl-1,11-undecanedioic Acid and Derivatives Thereof, Process for their Production and Use for the Production of Pharmaceutical Agents CYP4B1, CYP2B6, UGT2B7 SMN1; SMN2 2135/4885CYP3A4 15/4885CYP19A1 450/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.