Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Trifluoroacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ACLY | P53396 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.33 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4182370 | 1.00 | ALDH1A1 (0.35) | ALDH1A1TSHRACLYL3MBTL1F2 | |
| Trifluoroacetic Acid SCHEMBL27831673 | 0.97 | ALDH1A1 (0.33) | ALDH1A1TSHRACLYL3MBTL1F2 | |
| Dimethyl Sulfoxide SCHEMBL28260226 | 0.81 | CA1 (0.33) | CA2 | |
| Trifluoroacetic Acid SCHEMBL28747664 | 0.81 | ALDH1A1 (0.37) | ALDH1A1TSHRACLYL3MBTL1THRB | |
| Trifluoroacetic Acid SCHEMBL3499424 | 0.79 | — | — | |
| Trifluoroacetic Acid SCHEMBL72727 | 0.79 | — | — | |
| Trifluoroacetic Acid SCHEMBL1262416 | 0.79 | — | — | |
| Trifluoroacetic Acid SCHEMBL4598430 | 0.79 | — | — | |
| Trifluoroacetic Acid SCHEMBL7814389 | 0.79 | ALDH1A1 (0.44) | ALDH1A1TSHRACLYL3MBTL1THRB | |
| Trifluoroacetic Acid SCHEMBL2484766 | 0.79 | ALDH1A1 (0.44) | ALDH1A1TSHRACLYL3MBTL1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112174823-B | Intermediate for synthesizing 2, 2-dimethyl-3-oxetanone and preparation method and application thereof | 南京富润凯德生物医药有限公司 | 2023-12-01 | — | — | CN | claimed |
| CN-112174823-B | Intermediate for synthesizing 2, 2-dimethyl-3-oxetanone and preparation method and application thereof | 南京富润凯德生物医药有限公司 | 2023-12-01 | — | — | CN | disclosed |
| WO-2023204291-A1 | BICYCLOAMINE CARBOXAMIDE DERIVATIVE | 住友ファーマ株式会社 | 2023-10-26 | — | — | WO | disclosed |
| WO-2023202501-A1 | SUBSTITUTED PYRIDOPYRIMIDINONE COMPOUND, COMPOSITION COMPRISING SAME, AND USE THEREOF | 深圳市塔吉瑞生物医药有限公司 | 2023-10-26 | — | — | WO | disclosed |
| EP-4028130-A1 | BENZYL AMINE-CONTAINING 5,6-HETEROAROMATIC COMPOUNDS USEFUL AGAINST MYCOBACTERIAL INFECTION | Shionogi & Co., Ltd (JP) | 2022-07-20 | — | — | EP | disclosed |
| WO-2021060477-A1 | REAGENT FOR MEASURING SKIN SENSITIZATION, METHOD FOR MEASURING SKIN SENSITIZATION, AND COMPOUND | 富士フイルム株式会社 | 2021-04-01 | — | — | WO | disclosed |
| WO-2021050708-A1 | BENZYL AMINE-CONTAINING 5,6-HETEROAROMATIC COMPOUNDS USEFUL AGAINST MYCOBACTERIAL INFECTION | SHIONOGI & CO., LTD. (JP) | 2021-03-18 | — | — | WO | disclosed |
| CN-105307662-B | 4 '-fluoro-2' -methyl substituted nucleoside derivatives | 里博科学有限责任公司 | 2019-06-04 | — | — | CN | disclosed |
| CN-107428731-A | Substituted 2-hydro-pyrazole derivatives as anti-cancer agents | 正大天晴药业集团股份有限公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-104478855-B | 3-amino-4-((E)-pyridine-2(1-hydro)-alkenyl acetonitrile)-1,8-naphthalimide derivative | 上海应用技术学院 | 2017-02-22 | — | — | CN | disclosed |
| CN-1158127-A | Novel N-polynaphtho-fused lactams | NOVO NORDISK AS (DK) | 1997-08-27 | — | — | CN | disclosed |
| EP-0777668-A1 | NOVEL N-SUBSTITUTED NAPHTHOFUSED LACTAMS | NOVO NORDISK A/S (DK) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996005195-A1 | NOVEL N-SUBSTITUTED NAPHTHOFUSED LACTAMS | NOVO NORDISK A/S (DK) | 1996-02-22 | — | — | WO | disclosed |
| EP-0268229-B1 | IMIDAZOLIDINONE COMPOUNDS, PROCESSES FOR PREPARATION THEREOF, COMPOSITIONS COMPRISING SUCH COMPOUNDS, AND THE USE OF SUCH COMPOUNDS FOR THE MANUFACTURE OF MEDICAMENTS HAVING THERAPEUTIC VALUE | TANABE SEIYAKU CO., LTD. (JP) | 1992-07-08 | — | — | EP | disclosed |
| US-5026898-A | Cell process controllers | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1991-06-25 | — | — | US | disclosed |
| US-4924023-A | MEDICINE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-05-08 | — | — | US | disclosed |
| US-4886817-A | Imidazolidinones as brain activators | TANABE SEIYAKU CO., LTD. (JP) | 1989-12-12 | — | — | US | disclosed |
| US-4873355-A | Process for regioselectively preparing phosphorylated inositols and other cyclitols | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0268229-A2 | Imidazolidinone compounds, processes for preparation thereof, compositions comprising such compounds, and the use of such compounds for the manufacture of medicaments having therapeutic value | TANABE SEIYAKU CO., LTD. (JP) | 1988-05-25 | — | — | EP | disclosed |
| US-4504478-A | Cephalosporin-1-oxide derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (FR) | 1985-03-12 | — | — | US | disclosed |