Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | VNN1 | O95497 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | EIF4E | P06730 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4069500 | 0.84 | HPGD (0.42) | PDE5APDE4APDE1APDE1BPDE4B | |
| Hydrochloric Acid SCHEMBL5500156 | 0.83 | HPGD (0.42) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL5501423 | 0.80 | HTR6 (0.34) | PDE5APDE1APDE1BPDE4DPDE7A | |
| Hydrochloric Acid SCHEMBL5506619 | 0.79 | HTR6 (0.33) | PDE5APDE1APDE1BPDE4DPDE7A | |
| SCHEMBL5504186 | 0.77 | F10 (0.35) | — | |
| SCHEMBL209326 | 0.77 | HSD11B1 (0.43) | PDE5APDE4APDE1APDE1BPDE4B | |
| SCHEMBL5509140 | 0.77 | ERN1 (0.43) | PDE5APDE1APDE1BPDE4DPDE7A | |
| Hydrochloric Acid SCHEMBL5504522 | 0.76 | ERN1 (0.43) | PDE5APDE1APDE1BPDE4DPDE7A | |
| SCHEMBL5499711 | 0.75 | DPP4 (0.36) | — | |
| SCHEMBL4198712 | 0.75 | PDE7B (0.36) | PDE5APDE4APDE1APDE1BPDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2016047-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2009-01-21 | — | — | EP | disclosed |
| WO-2007124337-A1 | BIPHENYL AMIDE LACTAM DERIVATIVES AS INHIBITORS OF 11- BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-01 | — | — | WO | disclosed |