SCHEMBL5504186

SCHEMBL5504186

O=C1CCCN1C1CCCC(Cc2c(Cl)cc(O)cc2Cl)C1

nearest known ligand 0.39

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
F10 P00742 3/20 0.35
DPP4 P27487 1/20 0.34
DPP8 Q6V1X1 1/20 0.34
DPP9 Q86TI2 1/20 0.34
ALOX5 P09917 1/20 0.31
KDM5A P29375 1/20 0.31
NPY5R Q15761 1/20 0.30
OPRL1 P41146 1/20 0.30
KAT8 Q9H7Z6 1/20 0.30
LTA4H P09960 1/20 0.30
KCNH2 Q12809 1/20 0.30
P2RX7 Q99572 1/20 0.30
SYK P43405 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5499711 0.88 DPP4 (0.36) F10DPP4DPP8DPP9OPRL1
SCHEMBL5503363 0.85 MMP13 (0.36) F10OPRL1
SCHEMBL5504207 0.85 MEN1 (0.33) F10DPP4DPP8DPP9P2RX7
SCHEMBL5502855 0.85 F10 (0.33) F10DPP4DPP8DPP9ALOX5
SCHEMBL5500707 0.85 F10 (0.33) F10DPP4DPP8DPP9ALOX5
SCHEMBL5501423 0.82 HTR6 (0.34) F10DPP4DPP8DPP9NPY5R
Hydrochloric Acid SCHEMBL5506619 0.82 HTR6 (0.33) F10DPP4DPP8DPP9NPY5R
SCHEMBL5503421 0.81 F10 (0.32) F10DPP4DPP8DPP9LTA4H
SCHEMBL5503355 0.80 MEN1 (0.34) F10DPP4DPP8DPP9
SCHEMBL5504601 0.80 HCN4 (0.37) F10DPP4DPP8DPP9P2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1807072-A1 CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 ELI LILLY AND COMPANY (US) 2007-07-18 EP claimed
WO-2006049952-A1 CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 ELI LILLY AND COMPANY (US) 2006-05-11 WO claimed
EP-1807072-A1 CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 ELI LILLY AND COMPANY (US) 2007-07-18 EP disclosed
WO-2006049952-A1 CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 ELI LILLY AND COMPANY (US) 2006-05-11 WO disclosed