Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.65 |
| ▸ | HTR3B | O95264 | 2/20 | 0.65 |
| ▸ | HTR3A | P46098 | 2/20 | 0.65 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.65 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.65 |
| ▸ | HTR1A | P08908 | 2/20 | 0.65 |
| ▸ | HTR2A | P28223 | 2/20 | 0.65 |
| ▸ | HTR7 | P34969 | 2/20 | 0.65 |
| ▸ | HTR6 | P50406 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.65 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | THRB | P10828 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.65 |
| ▸ | HTR2C | P28335 | 1/20 | 0.65 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.65 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.65 |
| ▸ | HTR2B | P41595 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067588 | 0.89 | HTR3E (0.56) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL11100857 | 0.87 | ALDH1A1 (0.75) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL6714846 | 0.87 | ALDH1A1 (0.75) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL30407444 | 0.83 | HTR3E (0.69) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL29595602 | 0.83 | HTR3E (0.69) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL1822683 | 0.83 | HTR3E (0.69) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL26770369 | 0.83 | HTR3E (0.69) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL9646111 | 0.82 | ALDH1A1 (0.73) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL11922752 | 0.82 | HTR3E (0.67) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL5277357 | 0.81 | HTR3E (0.56) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106083820-A | A kind of preparation method of 4 [(4 chlorphenyl) (2 pyridine radicals) methoxyl group] piperidines | 山东川成医药股份有限公司 | 2016-11-09 | — | — | CN | claimed |
| CN-105669652-A | Improved preparation method of bepotastine besilate | 石家庄格瑞药业有限公司 | 2016-06-15 | — | — | CN | claimed |
| CN-104151295-B | A kind of synthetic method of 2-[(4-chloro-phenyl-) (4-piperidyl oxygen base) methyl] pyridine | SHANDONG CHUANCHENG PHARMACEUTICAL CO., LTD. (CN) | 2015-12-30 | — | — | CN | claimed |
| CN-104693183-A | Synthetic method for 2-[(4-chlorphenyl) (4-piperidyl oxygroup) methyl] pyridine and derivate thereof | HAOYUAN CHEMEXPRESS CO LTD | 2015-06-10 | — | — | CN | claimed |
| CN-104151295-A | Synthesis method of 2-[(4-chlorphenyl)(4-piperidyloxyl)methyl]pyridine | SHANDONG CHUANCHENG PHARMACEUTICAL CO LTD | 2014-11-19 | — | — | CN | claimed |
| CN-114751874-A | 1-benzyl-4-ethylpiperazine derivatives as TRPV4-KCa2.3 coupling promoting agents and application thereof | 江南大学 | 2022-07-15 | — | — | CN | disclosed |
| EP-3515914-A1 | NOVEL 5 or 8-SUBSTITUTED IMIDAZO [1, 5-a]PYRIDINES AS SELECTIVE INHIBITORS OF INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BeiGene, Ltd. (KY) | 2019-07-31 | — | — | EP | disclosed |
| CN-109957585-A | A kind of method that biocatalysis technique prepares (S)-(4- chlorphenyl) -2- pyridinemethanol | 尚科生物医药（上海）有限公司 | 2019-07-02 | — | — | CN | disclosed |
| WO-2018054365-A1 | NOVEL 5 or 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS SELECTIVE INHIBITORS OF INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES | BEIGENE, LTD. (KY) | 2018-03-29 | — | — | WO | disclosed |
| CN-106083820-A | A kind of preparation method of 4 [(4 chlorphenyl) (2 pyridine radicals) methoxyl group] piperidines | 山东川成医药股份有限公司 | 2016-11-09 | — | — | CN | disclosed |
| CN-105669652-A | Improved preparation method of bepotastine besilate | 石家庄格瑞药业有限公司 | 2016-06-15 | — | — | CN | disclosed |
| CN-104151295-B | A kind of synthetic method of 2-[(4-chloro-phenyl-) (4-piperidyl oxygen base) methyl] pyridine | SHANDONG CHUANCHENG PHARMACEUTICAL CO., LTD. (CN) | 2015-12-30 | — | — | CN | disclosed |
| CN-104151295-B | A kind of synthetic method of 2-[(4-chloro-phenyl-) (4-piperidyl oxygen base) methyl] pyridine | SHANDONG CHUANCHENG PHARMACEUTICAL CO., LTD. (CN) | 2015-12-30 | — | — | CN | disclosed |
| CN-104693183-A | Synthetic method for 2-[(4-chlorphenyl) (4-piperidyl oxygroup) methyl] pyridine and derivate thereof | HAOYUAN CHEMEXPRESS CO LTD | 2015-06-10 | — | — | CN | disclosed |
| CN-104693183-A | Synthetic method for 2-[(4-chlorphenyl) (4-piperidyl oxygroup) methyl] pyridine and derivate thereof | HAOYUAN CHEMEXPRESS CO LTD | 2015-06-10 | — | — | CN | disclosed |
| CN-104693183-A | Synthetic method for 2-[(4-chlorphenyl) (4-piperidyl oxygroup) methyl] pyridine and derivate thereof | HAOYUAN CHEMEXPRESS CO LTD | 2015-06-10 | — | — | CN | disclosed |
| CN-104151295-A | Synthesis method of 2-[(4-chlorphenyl)(4-piperidyloxyl)methyl]pyridine | SHANDONG CHUANCHENG PHARMACEUTICAL CO LTD | 2014-11-19 | — | — | CN | disclosed |
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |
| CN-1538956-A | Spiro compounds | ������ҩ��ʽ���� | 2004-10-20 | — | — | CN | disclosed |