Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 3/20 | 0.36 |
| ▸ | METAP1 | P53582 | 1/20 | 0.36 |
| ▸ | CCR1 | P32246 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4065028 | 1.00 | METAP2 (0.36) | METAP2METAP1CCR1SMN1; SMN2LMNA | |
| SCHEMBL4066973 | 0.86 | HPGD (0.35) | CCR1LMNAALDH1A1HPGDKDM4E | |
| SCHEMBL6675011 | 0.86 | CCR1 (0.43) | CCR1LMNAALDH1A1 | |
| SCHEMBL4071319 | 0.84 | ESRRG (0.41) | CCR1MAPT | |
| SCHEMBL4060470 | 0.84 | PLAAT3 (0.41) | — | |
| SCHEMBL6169667 | 0.84 | CCR1 (0.43) | METAP2METAP1CCR1KDM4EMAPT | |
| SCHEMBL6832277 | 0.84 | CCR1 (0.41) | CCR1 | |
| SCHEMBL4064274 | 0.84 | CCR1 (0.41) | CCR1 | |
| SCHEMBL4064042 | 0.84 | CCR1 (0.43) | METAP2METAP1CCR1KDM4EMAPT | |
| SCHEMBL4067483 | 0.83 | RAB9A (0.40) | CCR1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966443-B1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER (US) | 2009-01-28 | — | — | EP | disclosed |