Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 9/20 | 0.46 |
| ▸ | JAK2 | O60674 | 6/20 | 0.46 |
| ▸ | JAK1 | P23458 | 5/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068973 | 0.92 | TYK2 (0.46) | POLBLCKMAPK14TYK2JAK2 | |
| SCHEMBL4068779 | 0.84 | NPC1 (0.51) | TYK2CYP3A4HPGDRAB9A | |
| SCHEMBL4061473 | 0.75 | DHODH (0.49) | POLBLCKMAPK14TYK2JAK2 | |
| SCHEMBL4070576 | 0.71 | DHODH (0.45) | LCKMAPK14TYK2JAK2JAK1 | |
| SCHEMBL11172310 | 0.71 | NPSR1 (0.48) | LCKMAPK14JAK2KMT2ANPSR1 | |
| SCHEMBL7384072 | 0.70 | TYK2 (0.65) | TYK2JAK2JAK1CYP3A4KMT2A | |
| SCHEMBL4063185 | 0.70 | POLB (0.54) | POLBTYK2JAK2JAK1CYP3A4 | |
| SCHEMBL4058533 | 0.69 | TYK2 (0.50) | POLBLCKMAPK14TYK2JAK2 | |
| SCHEMBL4061467 | 0.69 | POLB (0.53) | POLBTYK2JAK2JAK1CYP3A4 | |
| SCHEMBL11184085 | 0.68 | PTPN1 (0.53) | NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-B9 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2009-02-18 | — | — | EP | disclosed |
| EP-1028945-B1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC (US) | 2007-07-11 | — | — | EP | disclosed |