SCHEMBL4070757

SCHEMBL4070757

COc1ccc([SiH](C)C)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.61
CA2 P00918 3/20 0.61
CA7 P43166 2/20 0.61
CA9 Q16790 2/20 0.61
CA12 O43570 1/20 0.61
CA14 Q9ULX7 1/20 0.61
ACHE P22303 1/20 0.50
PKM P14618 1/20 0.48
TDP1 Q9NUW8 3/20 0.48
MAPK1 P28482 3/20 0.48
ALDH1A1 P00352 4/20 0.46
KDM4E B2RXH2 2/20 0.46
MAPT P10636 2/20 0.46
NPSR1 Q6W5P4 2/20 0.46
NPC1 O15118 1/20 0.46
GAA P10253 1/20 0.46
THRB P10828 1/20 0.46
RECQL P46063 1/20 0.46
RAB9A P51151 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL188297 0.80 ALDH1A1 (0.41) TDP1MAPK1ALDH1A1MAPTNPC1
SCHEMBL1986937 0.80 CA1 (0.65) CA1CA2CA7CA9CA12
SCHEMBL22643732 0.79 CA1 (0.55) CA1CA2CA7CA9CA12
SCHEMBL9304921 0.79 LMNA (0.60) CA1CA2ALDH1A1KDM4EMAPT
SCHEMBL148576 0.78
SCHEMBL2438805 0.78
1,4-Dimethoxybenzene SCHEMBL8489 0.78 CA1 (1.00) CA1CA2CA7CA9CA12
1,4-Dimethoxybenzene SCHEMBL21802643 0.78 CA1 (1.00) CA1CA2CA7CA9CA12
SCHEMBL3299022 0.76 CA1 (0.58) CA1CA2CA7CA9CA12
SCHEMBL8401606 0.74 CA1 (0.65) CA1CA2CA7CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117615793-A Antibody conjugates and their preparation 明峰治疗股份公司 2024-02-27 CN claimed
CN-120040492-A Method for synthesizing silanol by catalyzing and oxidizing silane with polyacid 辽宁科技大学 2025-05-27 CN disclosed
CN-119119106-A Method for preparing silanol by selective oxidation of hydrosilane under catalysis of nano porous palladium copper 大连理工大学 2024-12-13 CN disclosed
CN-118852230-A Preparation method of polysubstituted hydrosilane compound 中国科学院兰州化学物理研究所 2024-10-29 CN disclosed
CN-115073511-B Green synthesis method for oxidizing silane into silanol 台州学院 2024-09-13 CN disclosed
CN-118027090-A Method for generating silanol by oxidizing silane 吉林大学 2024-05-14 CN disclosed
CN-117615793-A Antibody conjugates and their preparation 明峰治疗股份公司 2024-02-27 CN disclosed
CN-117615794-A Checkpoint inhibitors conjugated to IL-2 and uses thereof 明峰治疗股份公司 2024-02-27 CN disclosed
CN-117615792-A Conjugates of checkpoint inhibitors with IL-2 and uses thereof 明峰治疗股份公司 2024-02-27 CN disclosed
CN-115996755-A Bifunctional molecules and methods of use thereof 旗舰创业创新VI有限责任公司 2023-04-21 CN disclosed
WO-2003100134-A1 ELECTROCHEMICAL METHOD FOR THE PRODUCTION OF ORGANOFUNCTIONAL SILANES Consortium für elektrochemische Industrie GmbH (DE) 2003-12-04 WO disclosed
US-5962435-A ANTICHOLESTEROL AGENT HOECHST MARION ROUSSEL, INC. (US) 1999-10-05 US disclosed
EP-0910384-A1 METHOD OF INHIBITING VASCULAR CELL ADHESION MOLECULE-1 AND TREATING CHRONIC INFLAMMATORY DISEASES WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS HOECHST MARION ROUSSEL, INC. (US) 1999-04-28 EP disclosed
US-5795876-A ANTIINFLAMMATORY AGENTS HOECHST MARION ROUSSSEL, INC. (US) 1998-08-18 US disclosed
WO-1997040837-A1 METHOD OF INHIBITING VASCULAR CELL ADHESION MOLECULE-1 AND TREATING CHRONIC INFLAMMATORY DISEASES WITH 2,6-DI-ALKYL-4-SILYL-PHENOLS HOECHST MARION ROUSSEL, INC. (US) 1997-11-06 WO disclosed
US-5677291-A Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols HOECHST MARION ROUSSEL, INC. (US) 1997-10-14 US disclosed
EP-0710241-A1 NOVEL SILYLATED BENZYLAMINE DERIVATIVES, SALTS THEREOF, METHODS OF MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PIERRE FABRE MEDICAMENT (FR) 1996-05-08 EP disclosed
WO-1995003313-A1 NOVEL SILYLATED BENZYLAMINE DERIVATIVES, SALTS THEREOF, METHODS OF MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM PIERRE FABRE MEDICAMENT (FR) 1995-02-02 WO disclosed
US-5235061-A 2,4-disilaalkanes; agriculture KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) 1993-08-10 US disclosed
US-4883789-A Substituted phenyltrialkylsilane insecticides FMC CORPORATION (US) 1989-11-28 US disclosed