Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 2/20 | 0.41 |
| ▸ | EIF4H | Q15056 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 2/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4061080 | 0.99 | RORC (0.41) | PABPC1EIF4HRORCCYP2C9PDE4A | |
| SCHEMBL4060642 | 0.88 | RORC (0.45) | PABPC1EIF4HRORCCYP2C9PDE4A | |
| Hydrochloric Acid SCHEMBL4242731 | 0.84 | ADRB2 (0.39) | RORCCYP2C9ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL4058546 | 0.84 | ATM (0.53) | PABPC1EIF4HRORCCYP2C9PDE4A | |
| SCHEMBL6082085 | 0.82 | PTGDR2 (0.44) | ADRB2NCF1AR | |
| Hydrochloric Acid SCHEMBL4063943 | 0.81 | NCF1 (0.45) | RORCCYP2C9PDE4AKCNH2LMNA | |
| SCHEMBL4060771 | 0.80 | PDE4A (0.40) | PABPC1EIF4HPDE4AKCNH2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL4239887 | 0.78 | KCNH2 (0.40) | KCNH2ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4244244 | 0.78 | PTGDR2 (0.45) | RORCKCNH2HTTSMN1; SMN2MEN1 | |
| SCHEMBL4236166 | 0.78 | RORC (0.39) | RORCSMN1; SMN2MEN1KMT2AADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1641791-B1 | 3-(GUANIDINOCARBONYL)HETEROCYCLE DERIVATIVES, PREPARATION PROCESS AND INTERMEDIATES OF THIS PROCESS, THEIR USE AS MEDICAMENTS, AND PHARMACEUTICAL COMPOSITIONS INCLUDING THEM | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-07-29 | — | — | EP | disclosed |