SCHEMBL4070899

SCHEMBL4070899

CCOC(=O)Oc1c(C)nnc(Cl)c1OC(=O)OCC

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.40
CUL4A Q13619 2/20 0.38
SOAT1 P35610 1/20 0.38
CASP1 P29466 2/20 0.35
CA12 O43570 1/20 0.33
CA1 P00915 1/20 0.33
CA2 P00918 1/20 0.33
CA9 Q16790 1/20 0.33
KMT2A Q03164 3/20 0.33
KDM4E B2RXH2 2/20 0.33
MAPT P10636 2/20 0.33
MEN1 O00255 2/20 0.33
ALOX15 P16050 1/20 0.33
POLB P06746 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
PDE4D Q08499 1/20 0.32
LMNA P02545 1/20 0.30
HSD17B10 Q99714 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
ALOX5 P09917 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11140980 0.74 ALDH1A1 (0.50) ALDH1A1CUL4ASOAT1KMT2AKDM4E
SCHEMBL8312577 0.71 PDE4D (0.45) ALDH1A1CUL4ASOAT1CA12CA1
SCHEMBL8567536 0.69 CUL4A (0.39) ALDH1A1CUL4ASOAT1KMT2AKDM4E
SCHEMBL19543205 0.68 CUL4A (0.52) ALDH1A1CUL4ASOAT1KMT2AKDM4E
SCHEMBL1245065 0.68 PDE4D (0.49) ALDH1A1CASP1CA12CA1CA2
SCHEMBL1577573 0.68 ALDH1A1 (0.43) ALDH1A1SOAT1CA2KMT2AKDM4E
SCHEMBL1401567 0.67 ALDH1A1 (0.52) ALDH1A1CUL4ASOAT1KMT2AKDM4E
SCHEMBL6569258 0.67 CACNA1F (0.48) ALDH1A1CUL4ASOAT1KMT2AMEN1
SCHEMBL20338236 0.67 PDE4D (0.47) ALDH1A1CASP1CA12CA1CA2
SCHEMBL9526526 0.66 ALDH1A1 (0.40) ALDH1A1CUL4ASOAT1KMT2AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2029589-A1 DIHYDRO-PYRROLOPYRIDINE-, DIHYDRO-PYRROLOPYRIDAZINE- AND DIHYDRO-PYRROLOPYRIMIDINE-DERIVATIVES AND USE THEREOF Bayer HealthCare AG (DE) 2009-03-04 EP disclosed
WO-2007137793-A1 DIHYDRO-PYRROLOPYRIDINE-, DIHYDRO-PYRROLOPYRIDAZINE- AND DIHYDRO-PYRROLOPYRIMIDINE-DERIVATIVES AND USE THEREOF BAYER HEALTHCARE AG (DE) 2007-12-06 WO disclosed