Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.40 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.40 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.40 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.38 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6569258 | 0.84 | CACNA1F (0.48) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9209083 | 0.82 | HTT (0.36) | POLBHTTNPC1RAB9A | |
| SCHEMBL7037546 | 0.79 | LMNA (0.38) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9524891 | 0.75 | TSHR (0.37) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7799763 | 0.69 | ALDH1A1 (0.40) | ALDH1A1SOAT1CUL4AKMT2APOLB | |
| SCHEMBL1401567 | 0.67 | ALDH1A1 (0.52) | ALDH1A1SOAT1CUL4AKMT2AMEN1 | |
| SCHEMBL9527107 | 0.67 | TSHR (0.48) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL11140980 | 0.66 | ALDH1A1 (0.50) | ALDH1A1SOAT1CUL4AKMT2AMEN1 | |
| SCHEMBL9524704 | 0.66 | ALDH1A1 (0.47) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9200767 | 0.66 | ALDH1A1 (0.40) | ALDH1A1CACNA1FCACNA1DCACNA1SCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337263-B1 | ISOXAZOL(ISOTHIAZOLS)-5-CARBOXAMIDES | BASF Aktiengesellschaft (DE) | 1993-03-17 | — | — | EP | disclosed |
| EP-0337263-A2 | Isoxazol(isothiazols)-5-carboxamides | BASF Aktiengesellschaft (DE) | 1989-10-18 | — | — | EP | disclosed |