Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.40 |
| ▸ | ACR | P10323 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4074699 | 0.96 | SMN1; SMN2 (0.43) | SMN1; SMN2KCNA5MTNR1AEGLN1ACR | |
| SCHEMBL1033120 | 0.89 | SMN1; SMN2 (0.47) | SMN1; SMN2KCNA5MTNR1AEGLN1THRA | |
| SCHEMBL1030683 | 0.85 | SMN1; SMN2 (0.47) | SMN1; SMN2MTNR1AEGLN1THRATHRB | |
| SCHEMBL4080190 | 0.83 | BCHE (0.43) | SMN1; SMN2MTNR1AEGLN1FAAHTHRA | |
| SCHEMBL1033035 | 0.82 | EGLN1 (0.47) | SMN1; SMN2EGLN1THRATHRB | |
| SCHEMBL8148476 | 0.82 | EGLN1 (0.53) | KCNA5EGLN1ACRHPGDHSD17B10 | |
| SCHEMBL1031021 | 0.81 | NPC1 (0.38) | SMN1; SMN2MTNR1AEGLN1HPGDHSD17B10 | |
| SCHEMBL4075081 | 0.81 | DHODH (0.44) | EGLN1HPGDHSD17B10THRATHRB | |
| SCHEMBL1034732 | 0.80 | NPC1 (0.38) | SMN1; SMN2MTNR1AEGLN1THRATHRB | |
| SCHEMBL1033428 | 0.78 | NPC1 (0.37) | SMN1; SMN2MTNR1AEGLN1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-0911340-B1 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2005-07-06 | — | — | EP | disclosed |
| EP-1538160-A1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN, INC. (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-0911340-A2 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |