Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 6/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 4/20 | 0.47 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP7 | P55210 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1033539 | 0.88 | EGLN1 (0.46) | EGLN1FTOBBOX1THRATHRB | |
| SCHEMBL1028658 | 0.88 | EGLN1 (0.46) | EGLN1FTOBBOX1KDM4EALDH1A1 | |
| SCHEMBL1028622 | 0.86 | EGLN1 (0.47) | EGLN1FTOBBOX1SMN1; SMN2KDM4E | |
| SCHEMBL1032271 | 0.85 | FTO (0.43) | EGLN1FTOBBOX1MEN1KMT2A | |
| SCHEMBL4070933 | 0.82 | SMN1; SMN2 (0.43) | EGLN1SMN1; SMN2THRATHRB | |
| SCHEMBL4074699 | 0.82 | SMN1; SMN2 (0.43) | EGLN1SMN1; SMN2THRATHRB | |
| SCHEMBL1033387 | 0.81 | FTO (0.46) | EGLN1FTOBBOX1MEN1KMT2A | |
| SCHEMBL1030683 | 0.81 | SMN1; SMN2 (0.47) | EGLN1FTOBBOX1SMN1; SMN2THRA | |
| SCHEMBL1033120 | 0.81 | SMN1; SMN2 (0.47) | EGLN1SMN1; SMN2THRATHRBALDH1A1 | |
| SCHEMBL4080190 | 0.79 | BCHE (0.43) | EGLN1SMN1; SMN2THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644336-B1 | NITROGEN-CONTAINING HETEROARYL COMPOUNDS AND THEIR USE IN INCREASING ENDOGENEOUS ERYTHROPOIETIN | FIBROGEN INC (US) | 2011-01-19 | — | — | EP | claimed |