Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 3/20 | 0.42 |
| ▸ | CNR2 | P34972 | 5/20 | 0.42 |
| ▸ | CNR1 | P21554 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.40 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4074699 | 0.87 | SMN1; SMN2 (0.43) | FAAHSMN1; SMN2MTNR1ATHRATHRB | |
| SCHEMBL1030683 | 0.85 | SMN1; SMN2 (0.47) | BCHELIPESMN1; SMN2MTNR1ATHRA | |
| SCHEMBL4076022 | 0.84 | THRA (0.41) | FAAHSMN1; SMN2MTNR1ATHRATHRB | |
| SCHEMBL8145604 | 0.83 | THRA (0.54) | CNR2CNR1THRATHRBEGLN1 | |
| SCHEMBL4070933 | 0.83 | SMN1; SMN2 (0.43) | FAAHSMN1; SMN2MTNR1ATHRATHRB | |
| SCHEMBL4078396 | 0.82 | ESR1 (0.40) | FAAHMTNR1ATHRATHRBEGLN1 | |
| SCHEMBL1033120 | 0.81 | SMN1; SMN2 (0.47) | BCHELIPESMN1; SMN2MTNR1ATHRA | |
| SCHEMBL4074682 | 0.79 | DHODH (0.39) | FAAHMTNR1A | |
| SCHEMBL1033035 | 0.79 | EGLN1 (0.47) | SMN1; SMN2THRATHRBEGLN1 | |
| SCHEMBL1033585 | 0.78 | THRA (0.41) | SMN1; SMN2MTNR1ATHRATHRBEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-0911340-B1 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2005-07-06 | — | — | EP | disclosed |
| EP-1538160-A1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN, INC. (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-0911340-A2 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |