SCHEMBL4070955

SCHEMBL4070955

C=CC(=O)Oc1c(Cl)cccc1C#N

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.36
PTGDR2 Q9Y5Y4 2/20 0.34
MRGPRX4 Q96LA9 2/20 0.34
ALDH1A1 P00352 5/20 0.34
KDM4E B2RXH2 4/20 0.34
HPGD P15428 4/20 0.34
MAPT P10636 3/20 0.34
HTT P42858 2/20 0.34
LMNA P02545 1/20 0.34
THRB P10828 2/20 0.33
TAS1R3 Q7RTX0 1/20 0.33
TAS1R1 Q7RTX1 1/20 0.33
TAS1R2 Q8TE23 1/20 0.33
DYRK1A Q13627 1/20 0.33
GSR P00390 1/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
LDHA P00338 1/20 0.33
LDHB P07195 1/20 0.33
ALOX15 P16050 2/20 0.33
HSD17B10 Q99714 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3423786 0.83 THRB (0.33) ALDH1A1HPGDTHRBALOX15HSD17B10
SCHEMBL1245242 0.82 TSHR (0.42) ALDH1A1KDM4EHPGDTHRBL3MBTL1
SCHEMBL28730327 0.80 KMT2A (0.39) KMT2APTGDR2MRGPRX4ALDH1A1KDM4E
SCHEMBL8145380 0.79 SMN1; SMN2 (0.41) KMT2AALDH1A1KDM4ELMNATHRB
SCHEMBL29657033 0.78 THRB (0.42) KMT2AALDH1A1KDM4EHPGDMAPT
SCHEMBL6658293 0.78 KMT2A (0.40) KMT2AALDH1A1HPGDTHRBGSR
SCHEMBL10499684 0.76 KDM4E (0.39) KMT2AALDH1A1KDM4EHPGDMAPT
SCHEMBL20534013 0.76 KMT2A (0.39) KMT2AALDH1A1KDM4EHPGDLMNA
SCHEMBL28910060 0.76 HPGD (0.40) KMT2AALDH1A1KDM4EHPGDMAPT
SCHEMBL28624346 0.76 KMT2A (0.39) KMT2AALDH1A1HPGDTHRBGSR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1649895-A2 Oxidizing composition comprising at least one electrophilic monomer and an oxidant with exception of benzoquinone L'OREAL (FR) 2006-04-26 EP claimed
EP-2065026-A1 Composition comprising, in an anhydrous cosmetically acceptable medium, electrophilic monomers and an acid, and its use for cosmetic treatment of hair L'Oreal (FR) 2009-06-03 EP disclosed
WO-2007125236-A1 COSMETIC COMPOSITION COMPRISING AT LEAST ONE ELECTROPHILIC MONOMER AND AT LEAST ONE CROSS-LINKED ELASTOMER ORGANOPOLYSILOXANE L'OREAL (FR) 2007-11-08 WO disclosed
EP-1847296-A2 Cosmetic composition comprising at least one electrophilic monomer, at least one fluorinated compound and a liquid organic solvent L'Oréal (FR) 2007-10-24 EP disclosed
EP-1847295-A2 Dyeing composition comprising a soluble fluorescent compound, at least one electrophilic monomer and at least one liquid organic solvent L'Oréal (FR) 2007-10-24 EP disclosed
EP-1844816-A2 Dyeing composition comprising at least one electrophilic monomer, one hydrophilic dye and one liquid organic solvent L'Oréal (FR) 2007-10-17 EP disclosed
EP-1844755-A1 Cosmetic composition comprising at least one dielectrophile monomer and a radical initiator L'Oréal (FR) 2007-10-17 EP disclosed
EP-1787680-A2 Cosmetic composition based on electrophilic monomers and a dispersion of surface-stabilised polymer particles L'Oréal (FR) 2007-05-23 EP disclosed
EP-1787630-A2 Cosmetic composition comprising pigment and/or filler surface pre-treated with organic agent and electrophilic monomer L'Oréal (FR) 2007-05-23 EP disclosed
EP-1649894-A2 Composition comprising electrophilic monomers and organic salts, use for treatment of keratinic materials L'OREAL (FR) 2006-04-26 EP disclosed
EP-1649895-A2 Oxidizing composition comprising at least one electrophilic monomer and an oxidant with exception of benzoquinone L'OREAL (FR) 2006-04-26 EP disclosed
EP-1647260-A1 use for cosmetic treatment of keratinic material of a composition comprising an electrophilic monomer and a non-siloxane polymer, thereby achieving a soft coating L'OREAL (FR) 2006-04-19 EP disclosed
EP-1647265-A1 Use for the cosmetic treatment of keratinous material of non sticky compositions based on electrophilic monomeres and non-silicon polymers L'OREAL (FR) 2006-04-19 EP disclosed
EP-1647264-A1 use for cosmetic treatment of keratinic material of a composition comprising an electrophilic monomer and a non-siloxane polymer, thereby achieving a rigid coating L'OREAL (FR) 2006-04-19 EP disclosed
EP-1647259-A1 use for treatment of keratinic materials of compositions comprising electrophilic monomers and agents forming liquid crystals L'OREAL (FR) 2006-04-19 EP disclosed
EP-1647308-A1 Use of a composition baded on electrophilic monomers and micro- or nano-particles L'OREAL (FR) 2006-04-19 EP disclosed
EP-1647258-A1 Hair care composition based on electrophilic monomers and lubricating solid micro or nano particles L'OREAL (FR) 2006-04-19 EP disclosed
EP-1647262-A1 Anhyrous cosmetic composition comprising electrophilic monomers and acid, and use for cosmetic treatment of hair L'OREAL (FR) 2006-04-19 EP disclosed
EP-1647263-A1 Double chamber aerosol device comprising electrophilic monomers and use for the cosmetic treatment of hair L'OREAL (FR) 2006-04-19 EP disclosed
EP-1647261-A1 Composition for the treatment of keratinous material based on electrophilic monomers and salts L'OREAL (FR) 2006-04-19 EP disclosed