Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 18/20 | 0.57 |
| ▸ | VEGFA | P15692 | 4/20 | 0.57 |
| ▸ | FLT1 | P17948 | 4/20 | 0.57 |
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.57 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.47 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL522880 | 0.86 | EGLN1 (0.73) | EGLN1VEGFAFLT1EGLN3BBOX1 | |
| SCHEMBL23580382 | 0.80 | NR4A2 (0.43) | EGLN1PKMSMN1; SMN2 | |
| SCHEMBL4082616 | 0.79 | EGLN1 (0.76) | EGLN1VEGFAFLT1EGLN3BBOX1 | |
| SCHEMBL4070258 | 0.76 | EGLN1 (0.68) | EGLN1EGLN3BBOX1FTO | |
| SCHEMBL17780841 | 0.75 | EGLN1 (0.62) | EGLN1VEGFAFLT1EGLN3FTO | |
| SCHEMBL4077943 | 0.74 | EGLN1 (0.50) | EGLN1BBOX1FTOPKMSMN1; SMN2 | |
| SCHEMBL14649383 | 0.73 | EGLN1 (0.73) | EGLN1VEGFAFLT1EGLN3BBOX1 | |
| SCHEMBL1921063 | 0.73 | EGLN1 (1.00) | EGLN1VEGFAFLT1EGLN3BBOX1 | |
| SCHEMBL30287600 | 0.73 | EGLN1 (1.00) | EGLN1VEGFAFLT1EGLN3BBOX1 | |
| SCHEMBL22369558 | 0.73 | FTO (0.53) | EGLN1VEGFAFLT1EGLN3FTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-0911340-B1 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2005-07-06 | — | — | EP | disclosed |
| EP-1538160-A1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN, INC. (US) | 2005-06-08 | — | — | EP | disclosed |
| US-6093730-A | AN ENZYME INHIBITORS OF PROLYL-4-HYDROXYLASE FOR TREATING FIBROTIC DISORDERS AND INHIBITING COLLAGEN BIOSYNTHESIS | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-07-25 | — | — | US | disclosed |
| EP-0911340-A2 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |