Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 9/20 | 0.50 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23580382 | 0.81 | NR4A2 (0.43) | EGLN1KMT2AKDM4EALDH1A1MAPT | |
| SCHEMBL522880 | 0.80 | EGLN1 (0.73) | EGLN1BBOX1FTO | |
| SCHEMBL4077946 | 0.76 | HAVCR2 (0.38) | EGLN1HAVCR2KMT2AMEN1KDM4E | |
| SCHEMBL4077902 | 0.76 | CA12 (0.46) | EGLN1KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL4070970 | 0.74 | EGLN1 (0.57) | EGLN1PKMBBOX1FTOSMN1; SMN2 | |
| SCHEMBL8150746 | 0.74 | LDHA (0.50) | EGLN1KMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL754068 | 0.72 | CYP1A2 (0.46) | EGLN1HAVCR2KMT2AMEN1KDM4E | |
| Water SCHEMBL2493601 | 0.72 | HAVCR2 (0.43) | EGLN1HAVCR2KMT2AMEN1KDM4E | |
| SCHEMBL754063 | 0.72 | ATM (0.46) | EGLN1HAVCR2KMT2AMEN1KDM4E | |
| SCHEMBL10583391 | 0.70 | KDM4E (0.66) | HAVCR2KMT2AMEN1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-0911340-B1 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2005-07-06 | — | — | EP | disclosed |
| EP-1538160-A1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN, INC. (US) | 2005-06-08 | — | — | EP | disclosed |
| CN-1117079-C | Substituted isoquinoline-3-formamides compounds, its preparing method and its use as medicine | FIBRE GENE INC (US) | 2003-08-06 | — | — | CN | disclosed |
| US-6093730-A | AN ENZYME INHIBITORS OF PROLYL-4-HYDROXYLASE FOR TREATING FIBROTIC DISORDERS AND INHIBITING COLLAGEN BIOSYNTHESIS | HOECHST MARION ROUSSEL DEUTSCHLAND GMBH (DE) | 2000-07-25 | — | — | US | disclosed |
| CN-1218802-A | Substituted isoquinoline-3-formamides compounds, its preparing method and its use as medicine | HOECHST MARION ROUSSEL CO LTD (DE) | 1999-06-09 | — | — | CN | disclosed |
| EP-0911340-A2 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |