Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 7/20 | 0.49 |
| ▸ | REN | P00797 | 3/20 | 0.45 |
| ▸ | ANPEP | P15144 | 2/20 | 0.43 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.43 |
| ▸ | LAP3 | P28838 | 3/20 | 0.43 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.43 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068098 | 0.91 | CCR1 (0.49) | CCR1RENANPEPERAP2ERAP1 | |
| SCHEMBL4071320 | 0.91 | CCR1 (0.48) | CCR1RENANPEPLAP3RNPEP | |
| SCHEMBL4068003 | 0.91 | CCR1 (0.58) | CCR1ALDH1A1CYP3A4 | |
| SCHEMBL4060474 | 0.90 | CCR1 (0.47) | CCR1RENANPEPERAP2ERAP1 | |
| SCHEMBL4071798 | 0.87 | KMT2A (0.50) | CCR1RENANPEPLAP3RNPEP | |
| SCHEMBL4063495 | 0.86 | CA2 (0.52) | CCR1 | |
| SCHEMBL4070822 | 0.85 | ADAM17 (0.47) | CCR1RENANPEPLAP3RNPEP | |
| SCHEMBL4066448 | 0.85 | REN (0.45) | CCR1RENANPEPLAP3RNPEP | |
| SCHEMBL4066974 | 0.85 | CCR1 (0.49) | CCR1RENANPEPLAP3RNPEP | |
| SCHEMBL6675017 | 0.84 | CCR1 (0.61) | CCR1RENANPEPLAP3RNPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966443-B1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER (US) | 2009-01-28 | — | — | EP | disclosed |