Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MMP1 | P03956 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | MMP8 | P22894 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1098525 | 1.00 | ALDH1A1 (0.35) | ALDH1A1MEN1KMT2ADPP4DPP7 | |
| SCHEMBL2248603 | 0.87 | DPP7 (0.40) | DPP4DPP7DPP8 | |
| SCHEMBL1587326 | 0.84 | CHRNB2 (0.42) | ALDH1A1MEN1KMT2ADPP4DPP7 | |
| SCHEMBL13324885 | 0.83 | MEN1 (0.41) | ALDH1A1MEN1KMT2ARORCROCK2 | |
| SCHEMBL3319718 | 0.80 | DPP4 (0.41) | DPP4DPP7DPP8CYP3A4 | |
| SCHEMBL3311754 | 0.80 | DPP4 (0.41) | DPP4DPP7DPP8CYP3A4 | |
| SCHEMBL3353105 | 0.78 | ALDH1A1 (0.33) | ALDH1A1MEN1KMT2ADPP4DPP7 | |
| SCHEMBL3298525 | 0.78 | MMP1 (0.44) | ALDH1A1MEN1KMT2ADPP4DPP7 | |
| SCHEMBL1417346 | 0.78 | MMP1 (0.44) | ALDH1A1MEN1KMT2ADPP4DPP7 | |
| SCHEMBL3288873 | 0.78 | MMP1 (0.44) | ALDH1A1MEN1KMT2ADPP4DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090270450-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-10-29 | — | — | US | claimed |
| EP-2084134-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2009-08-05 | — | — | EP | claimed |
| WO-2008056148-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-05-15 | — | — | WO | claimed |
| US-20090270450-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2009-10-29 | — | — | US | disclosed |
| EP-2084134-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2009-08-05 | — | — | EP | disclosed |
| WO-2008056148-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270450-A1 | CHEMICAL COMPOUNDS | CSF1R, CSF3R, FLT3 | ALDH1A1 753/4885MEN1 291/4885KMT2A 1288/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.