Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK4 | O96013 | 2/20 | 0.65 |
| ▸ | PLK4 | O00444 | 1/20 | 0.65 |
| ▸ | IGF1R | P08069 | 12/20 | 0.53 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29618398 | 0.79 | ULK1 (0.65) | PAK4NTRK1PAK1 | |
| SCHEMBL786513 | 0.79 | ULK1 (0.65) | PAK4NTRK1PAK1 | |
| SCHEMBL2317829 | 0.79 | IGF1R (0.75) | IGF1RNTRK1 | |
| SCHEMBL4069145 | 0.78 | PAK4 (0.69) | PAK4NTRK1PAK1 | |
| SCHEMBL4073719 | 0.78 | PAK4 (0.48) | PAK4IGF1RNTRK1PAK1 | |
| SCHEMBL4070230 | 0.78 | NTRK1 (0.63) | PAK4NTRK1PAK1 | |
| SCHEMBL219252 | 0.78 | IGF1R (0.66) | IGF1RNTRK1 | |
| SCHEMBL4067519 | 0.77 | IGF1R (0.53) | PAK4IGF1RNTRK1PAK1 | |
| SCHEMBL4072593 | 0.77 | IGF1R (0.48) | PAK4IGF1RNTRK1PAK1 | |
| SCHEMBL4071502 | 0.76 | NTRK1 (0.61) | PAK4IGF1RNTRK1PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |