Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | HRH1 | P35367 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.52 |
| ▸ | HTR1B | P28222 | 1/20 | 0.52 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25008394 | 0.95 | SIGMAR1 (0.63) | SIGMAR1HTR2AHRH1 | |
| SCHEMBL8084177 | 0.91 | SIGMAR1 (0.58) | SIGMAR1HTR2AHRH1SMN1; SMN2HTR1D | |
| SCHEMBL1967142 | 0.89 | HTR2A (0.56) | SIGMAR1HTR2AHRH1MPO | |
| SCHEMBL7982542 | 0.89 | SIGMAR1 (0.55) | SIGMAR1HTR2AHRH1SMN1; SMN2HTR1D | |
| SCHEMBL11934865 | 0.87 | SIGMAR1 (0.54) | SIGMAR1HTR2AHRH1 | |
| SCHEMBL13438744 | 0.87 | SIGMAR1 (0.54) | SIGMAR1HTR2AHRH1 | |
| SCHEMBL23468503 | 0.84 | MAOA (0.66) | SIGMAR1MPO | |
| SCHEMBL10630701 | 0.83 | L3MBTL1 (0.68) | — | |
| SCHEMBL9909029 | 0.83 | SIGMAR1 (0.49) | SIGMAR1HTR2AHRH1SMN1; SMN2HTR1D | |
| SCHEMBL9906703 | 0.83 | SLC6A2 (0.47) | SIGMAR1HTR2AHRH1SMN1; SMN2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2119702-A1 | AMIDE DERIVATIVE | Dainippon Sumitomo Pharma Co., Ltd. (JP) | 2009-11-18 | — | — | EP | disclosed |
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |