Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | CES2 | O00748 | 2/20 | 0.58 |
| ▸ | CES1 | P23141 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18869856 | 1.00 | LMNA (0.65) | LMNAMAPK1CES2CES1HPGD | |
| SCHEMBL27329628 | 1.00 | LMNA (0.65) | LMNAMAPK1CES2CES1HPGD | |
| Hydrochloric Acid SCHEMBL9617550 | 0.98 | LMNA (0.62) | LMNAMAPK1CES2CES1HPGD | |
| SCHEMBL28835827 | 0.98 | LMNA (0.62) | LMNAMAPK1CES2CES1HPGD | |
| Oxalic Acid SCHEMBL28129989 | 0.95 | LMNA (0.60) | LMNAMAPK1CES2CES1HPGD | |
| Acetaldehyde SCHEMBL11445863 | 0.89 | LMNA (0.54) | LMNAMAPK1CES2CES1HPGD | |
| SCHEMBL11877612 | 0.88 | LMNA (0.52) | LMNAMAPK1CES2CES1HPGD | |
| SCHEMBL8423523 | 0.81 | LMNA (0.60) | LMNAMAPK1CES2CES1HPGD | |
| Mandelic Acid SCHEMBL29777368 | 0.79 | LMNA (1.00) | LMNAMAPK1CES2CES1HPGD | |
| Mandelic Acid SCHEMBL255601 | 0.79 | LMNA (1.00) | LMNAMAPK1CES2CES1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112694488-B | Synthesis method of L-type cefamandole nafate | 苏州盛达药业有限公司 | 2022-04-22 | — | — | CN | claimed |
| CN-113354534-A | Preparation method of D- (-) -formyl mandelic acid chloride | 江西科苑生物股份有限公司 | 2021-09-07 | — | — | CN | claimed |
| CN-112694488-A | Synthesis method of L-type cefamandole nafate | 苏州盛达药业有限公司 | 2021-04-23 | — | — | CN | claimed |
| CN-110204557-A | A kind of preparation method of Mandokef sodio-derivative | 苏州盛达药业有限公司 | 2019-09-06 | — | — | CN | claimed |
| CN-106565750-B | A kind of synthetic method of dextrorotation Mandokef acid | 哈药集团制药总厂 | 2018-09-11 | — | — | CN | claimed |
| CN-107698515-A | A kind of preparation method of benzimidazole complex compound | 拉萨泰达医药科技有限公司 | 2018-02-16 | — | — | CN | claimed |
| CN-106565750-A | Synthesis method for dextrorotation cefamandole nafate | 哈药集团制药总厂 | 2017-04-19 | — | — | CN | claimed |
| CN-106380526-A | O-alpha-methyl mandelate-N-trimethyl chitosan quaternary ammonium salt as well as preparation method and application thereof | 湖南工业大学 | 2017-02-08 | — | — | CN | claimed |
| CN-105399754-A | Preparation method for sodium cefamandole | CHINA UNION CHEMPHARMA (SUZHOU) CO LTD | 2016-03-16 | — | — | CN | claimed |
| CN-103319335-B | Preparation method of D-(-)-O-methyl mandelic acid chloride | ZHANG ZHENXIA | 2014-12-03 | — | — | CN | claimed |
| CN-103319335-A | Preparation method of D-(-)-O-methyl mandelic acid chloride | ZHANG ZHENXIA | 2013-09-25 | — | — | CN | claimed |
| CN-102816172-A | Preparation process of cefamandole nafate | CHINA UNION CHEMPHARMA SUZHOU CO LTD | 2012-12-12 | — | — | CN | claimed |
| CN-101880290-A | Preparation method of cefamandole nafate | HAINAN NEW ZHONGZHENG PHARMACEUTICAL CO LTD | 2010-11-10 | — | — | CN | claimed |
| CN-101085781-B | Method for preparing cefonicid or its medicinal salt and intermediate | SHENZHEN SALUBRIS PHARM CO LTD | 2010-05-26 | — | — | CN | claimed |
| CN-101085781-A | Method for preparing cefonicid or its medicinal salt and intermediate | SHENZHEN SALUBRIS PHARMACEUTIC (CN) | 2007-12-12 | — | — | CN | claimed |
| CN-112552343-B | Axial chiral naphthalene-indole phosphine catalyst and preparation method and application thereof | 江苏师范大学 | 2023-03-14 | — | — | CN | disclosed |
| CN-112694488-B | Synthesis method of L-type cefamandole nafate | 苏州盛达药业有限公司 | 2022-04-22 | — | — | CN | disclosed |
| US-4005074-A | Process for cleaving an imido side chain from penicillins and cephalosporins | ELI LILLY AND COMPANY (US) | 1977-01-25 | — | — | US | disclosed |
| US-4001239-A | CEPHALOSPORIN CLEAVAGE PROCESS | ELI LILLY AND COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
| US-3994888-A | Cephalosporin cleavage process | ELI LILLY AND COMPANY (US) | 1976-11-30 | — | — | US | disclosed |