Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.37 |
| ▸ | CHRNG | P07510 | 1/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | CHRND | Q07001 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3721647 | 0.78 | LMNA (0.53) | SMN1; SMN2LMNAALDH1A1MAPTTDP1 | |
| SCHEMBL6260397 | 0.77 | POLB (0.50) | SMN1; SMN2CYP3A4KMT2ACYP1A2CYP2C19 | |
| SCHEMBL19758134 | 0.75 | SMN1; SMN2 (0.54) | SMN1; SMN2LMNAMAPTTDP1CYP3A4 | |
| SCHEMBL14122188 | 0.75 | TDP1 (0.72) | SMN1; SMN2LMNAALDH1A1TDP1CYP1A2 | |
| SCHEMBL4071020 | 0.74 | ADRA2A (0.49) | ALDH1A1MAPTKMT2ASLC6A2SLC6A4 | |
| SCHEMBL4079547 | 0.73 | SCN5A (0.37) | SMN1; SMN2LMNACYP3A4KMT2ACYP1A2 | |
| SCHEMBL900880 | 0.73 | LMNA (0.48) | SMN1; SMN2LMNAALDH1A1MAPTTDP1 | |
| SCHEMBL14122214 | 0.72 | MEN1 (0.53) | SMN1; SMN2LMNAALDH1A1MAPTTDP1 | |
| SCHEMBL14122615 | 0.72 | MEN1 (0.53) | SMN1; SMN2LMNAALDH1A1MAPTTDP1 | |
| SCHEMBL14122213 | 0.72 | MEN1 (0.53) | SMN1; SMN2LMNAALDH1A1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066673-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | ChemBridge Research Laboratories, Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |