Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.72 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.72 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.72 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.72 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | AHR | P35869 | 1/20 | 0.56 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | HK1 | P19367 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL407439 | 0.85 | NPC1 (0.70) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4227502 | 0.84 | NPC1 (1.00) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL29365738 | 0.84 | NPC1 (1.00) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL10032 | 0.84 | NPC1 (1.00) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL1196991 | 0.83 | NPC1 (0.57) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| Hydrochloric Acid SCHEMBL30293252 | 0.82 | NPC1 (0.96) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9056394 | 0.80 | NPC1 (0.64) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL14559393 | 0.79 | ACVR1 (0.52) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL20073842 | 0.79 | NPC1 (0.88) | NPC1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2086488 | 0.79 | NPC1 (0.62) | NPC1MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6866864-B2 | Compositions and methods of use in the treatment of angiogenesis and vascular-related disorders | Mousa, Ahmed (US) | 2005-03-15 | — | — | US | disclosed |
| US-20010053356-A1 | Garlic ingredients and antioxidants in the prevention and treatment of vascular-related disorders and pathological angiogenesis-mediated disorders | MOUSA AHMED (US) | 2001-12-20 | — | — | US | disclosed |