Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.68 |
| ▸ | GAA | P10253 | 2/20 | 0.68 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.65 |
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.54 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.52 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | PRNP | P04156 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3764417 | 0.84 | SHMT2 (0.60) | POLBGAASHMT2ABCG2ABCB1 | |
| SCHEMBL7914641 | 0.82 | MAPT (0.64) | POLBSHMT2ABCG2NPC1ALOX15 | |
| SCHEMBL3759465 | 0.81 | KDR (0.64) | POLBGAANPC1RAB9ARXFP1 | |
| SCHEMBL17792718 | 0.79 | SHMT2 (1.00) | POLBSHMT2ABCG2MAPT | |
| SCHEMBL3751477 | 0.79 | ABCG2 (0.67) | POLBSHMT2ABCG2RAB9AABCB1 | |
| SCHEMBL13056966 | 0.79 | EGFR (0.59) | POLBSHMT2ABCG2NPC1RAB9A | |
| SCHEMBL28478249 | 0.75 | ABCG2 (0.65) | POLBGAAABCG2ABCB1ABCC1 | |
| SCHEMBL2256504 | 0.75 | ABCG2 (0.73) | POLBABCG2ABCB1ABCC1MAPT | |
| SCHEMBL12135739 | 0.75 | GAA (0.65) | POLBGAAMAPT | |
| SCHEMBL2255930 | 0.73 | ABCG2 (1.00) | GAAABCG2NPC1RAB9AABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833803-A4 | PHARMACEUTICAL COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | MYRIAD GENETICS INC (US) | 2009-08-05 | — | — | EP | disclosed |
| EP-1833803-A2 | PHARMACEUTICAL COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | MYRIAD GENETICS, INC. (US) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006074223-A2 | PHARMACEUTICAL COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF | MYRIAD GENETICS, INC. (US) | 2006-07-13 | — | — | WO | disclosed |