Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.57 |
| ▸ | DRD3 | P35462 | 11/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.54 |
| ▸ | DRD4 | P21917 | 2/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | HTR2C | P28335 | 2/20 | 0.54 |
| ▸ | HTR7 | P34969 | 2/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.54 |
| ▸ | HRH1 | P35367 | 2/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | DRD5 | P21918 | 1/20 | 0.54 |
| ▸ | HTR2B | P41595 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29282523 | 0.77 | DRD2 (0.62) | DRD2DRD3HTR1AADRA2ADRD4 | |
| SCHEMBL30890931 | 0.77 | DRD2 (0.62) | DRD2DRD3HTR1AADRA2ADRD4 | |
| SCHEMBL29282525 | 0.77 | DRD2 (0.62) | DRD2DRD3HTR1AADRA2ADRD4 | |
| SCHEMBL4084481 | 0.77 | DRD2 (0.58) | DRD2DRD3HTR1AADRA2ADRD4 | |
| SCHEMBL18073598 | 0.75 | DRD2 (0.75) | DRD2DRD3HTR1AADRA2ADRD4 | |
| SCHEMBL18950703 | 0.75 | DRD2 (0.72) | DRD2DRD3HTR1AADRA2ADRD4 | |
| SCHEMBL18950687 | 0.75 | DRD2 (0.75) | DRD2DRD3HTR1AADRA2ADRD4 | |
| SCHEMBL21795356 | 0.74 | DRD2 (0.88) | DRD2DRD3HTR1AADRA2ADRD4 | |
| SCHEMBL4075434 | 0.74 | DRD2 (0.56) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL31708210 | 0.74 | DRD2 (0.82) | DRD2DRD3HTR1AADRA2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7473692-B2 | Sulfonamide derivatives as D3-receptor ligands | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2009-01-06 | — | — | US | claimed |
| EP-1438302-B1 | NEW SULFONAMIDE DERIVATIVES AS D3-RECEPTOR LIGANDS | RICHTER GEDEON NYRT (HU) | 2012-05-30 | — | — | EP | disclosed |