Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.58 |
| ▸ | DRD3 | P35462 | 8/20 | 0.58 |
| ▸ | HTR1A | P08908 | 3/20 | 0.57 |
| ▸ | DRD4 | P21917 | 3/20 | 0.57 |
| ▸ | HTR2A | P28223 | 3/20 | 0.57 |
| ▸ | HTR2C | P28335 | 3/20 | 0.57 |
| ▸ | DRD1 | P21728 | 2/20 | 0.57 |
| ▸ | HTR2B | P41595 | 2/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | HTR7 | P34969 | 2/20 | 0.56 |
| ▸ | HRH1 | P35367 | 2/20 | 0.56 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | DRD5 | P21918 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4254856 | 0.86 | DRD2 (0.56) | DRD2DRD3DRD4HTR2AADRA1A | |
| SCHEMBL4084512 | 0.80 | DRD2 (0.48) | DRD2DRD3HTR1AHTR2AADRA1A | |
| SCHEMBL30890931 | 0.80 | DRD2 (0.62) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL29282525 | 0.80 | DRD2 (0.62) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL29282523 | 0.80 | DRD2 (0.62) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL4079923 | 0.79 | DRD2 (0.51) | DRD2DRD3HTR1AHTR2AADRA1A | |
| SCHEMBL4075285 | 0.79 | DRD3 (0.57) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL4081134 | 0.78 | DRD2 (0.59) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL4081131 | 0.78 | DRD2 (0.59) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL22302939 | 0.78 | DRD2 (0.53) | DRD2DRD3HTR1ADRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7473692-B2 | Sulfonamide derivatives as D3-receptor ligands | RICHTER GEDEON VEGYESZETI GYAR RT. (HU) | 2009-01-06 | — | — | US | claimed |
| EP-1438302-B1 | NEW SULFONAMIDE DERIVATIVES AS D3-RECEPTOR LIGANDS | RICHTER GEDEON NYRT (HU) | 2012-05-30 | — | — | EP | disclosed |