Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | SSTR1 | P30872 | 6/20 | 0.48 |
| ▸ | SSTR2 | P30874 | 6/20 | 0.48 |
| ▸ | SSTR4 | P31391 | 6/20 | 0.48 |
| ▸ | SSTR3 | P32745 | 6/20 | 0.48 |
| ▸ | SSTR5 | P35346 | 6/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4892323 | 0.96 | SSTR1 (0.50) | HRH3HRH4SSTR1SSTR2SSTR4 | |
| SCHEMBL30005824 | 0.81 | LOXL2 (0.55) | HRH3LOXL2IDO1 | |
| SCHEMBL6860219 | 0.79 | LOXL2 (0.64) | HRH3HRH4LOXL2CHRNA7 | |
| SCHEMBL3195577 | 0.77 | LOXL2 (0.58) | HRH3LOXL2IDO1CHRNA7OPRK1 | |
| SCHEMBL14294327 | 0.77 | BCHE (0.52) | HRH3HRH4LOXL2CHRNA7 | |
| SCHEMBL4075672 | 0.75 | LOXL2 (0.49) | SSTR1SSTR2SSTR4SSTR3SSTR5 | |
| SCHEMBL31059889 | 0.75 | LOXL2 (0.69) | HRH3HRH4LOXL2CHRNA7 | |
| SCHEMBL7169246 | 0.75 | LOXL2 (0.69) | HRH3HRH4LOXL2CHRNA7 | |
| SCHEMBL5935752 | 0.73 | LOXL2 (0.46) | HRH4SSTR1SSTR2SSTR4SSTR3 | |
| SCHEMBL4069939 | 0.73 | TDP1 (0.64) | HRH3HRH4IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |