Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.49 |
| ▸ | IDO1 | P14902 | 2/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SSTR1 | P30872 | 1/20 | 0.39 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.39 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.39 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7360798 | 0.82 | LOXL2 (0.58) | LOXL2IDO1OPRK1F2 | |
| SCHEMBL4075676 | 0.75 | HRH3 (0.52) | LOXL2IDO1OPRK1SSTR1SSTR2 | |
| SCHEMBL4892323 | 0.74 | SSTR1 (0.50) | LOXL2IDO1OPRK1SSTR1SSTR2 | |
| SCHEMBL4069935 | 0.74 | TSHR (0.58) | IDO1TSHR | |
| SCHEMBL7355775 | 0.73 | LOXL2 (0.59) | LOXL2 | |
| SCHEMBL653529 | 0.73 | LOXL2 (0.63) | LOXL2IDO1OPRK1 | |
| SCHEMBL6941005 | 0.72 | TSHR (0.67) | IDO1TSHR | |
| SCHEMBL2592547 | 0.71 | LOXL2 (0.60) | LOXL2IDO1OPRK1 | |
| SCHEMBL30105384 | 0.71 | LOXL2 (0.60) | LOXL2IDO1OPRK1F2 | |
| SCHEMBL3193871 | 0.71 | LOXL2 (0.60) | LOXL2IDO1OPRK1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415986-B1 | SPIRO ISOBENZOFURANES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | BANYU PHARMA CO LTD (JP) | 2009-04-08 | — | — | EP | disclosed |
| US-7205417-B2 | Spiro compounds | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2007-04-17 | — | — | US | disclosed |