Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.47 |
| ▸ | SMO | Q99835 | 3/20 | 0.41 |
| ▸ | MTTP | P55157 | 2/20 | 0.41 |
| ▸ | APOB | P04114 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082951 | 0.88 | HDAC1 (0.48) | HDAC1HDAC8HDAC6OPRM1OPRD1 | |
| SCHEMBL4084233 | 0.85 | OPRM1 (0.57) | HDAC1OPRM1OPRD1OPRK1SMO | |
| SCHEMBL12650844 | 0.84 | HDAC1 (0.50) | HDAC1HDAC8HDAC6OPRM1OPRD1 | |
| SCHEMBL4480489 | 0.82 | OPRM1 (0.52) | HDAC1OPRM1OPRD1OPRK1SMO | |
| SCHEMBL12607941 | 0.81 | OPRM1 (0.55) | HDAC1OPRM1OPRD1OPRK1SMO | |
| SCHEMBL4074327 | 0.81 | OPRM1 (0.56) | HDAC1OPRM1OPRD1OPRK1SMO | |
| SCHEMBL4071959 | 0.81 | OPRM1 (0.53) | HDAC1OPRM1OPRD1OPRK1SMO | |
| SCHEMBL4478715 | 0.81 | OPRM1 (0.64) | HDAC1OPRM1OPRD1OPRK1SMO | |
| SCHEMBL4075949 | 0.80 | OPRM1 (0.57) | HDAC1OPRM1OPRD1OPRK1SMO | |
| Hydrochloric Acid SCHEMBL3337917 | 0.80 | OPRM1 (0.55) | HDAC1OPRM1OPRD1OPRK1SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |