Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 8/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4074327 | 0.91 | OPRM1 (0.56) | OPRM1OPRD1OPRK1HDAC1ADRB1 | |
| SCHEMBL4487306 | 0.87 | OPRM1 (0.50) | OPRM1OPRD1OPRK1HDAC1HTR1D | |
| SCHEMBL4084233 | 0.85 | OPRM1 (0.57) | OPRM1OPRD1OPRK1HDAC1HTR1D | |
| SCHEMBL4490634 | 0.84 | OPRK1 (0.52) | OPRM1OPRD1OPRK1HDAC1PRMT5 | |
| SCHEMBL12607941 | 0.83 | OPRM1 (0.55) | OPRM1OPRD1OPRK1HDAC1PRMT5 | |
| SCHEMBL4075949 | 0.82 | OPRM1 (0.57) | OPRM1OPRD1OPRK1HDAC1ADRB1 | |
| Hydrochloric Acid SCHEMBL3337917 | 0.82 | OPRM1 (0.55) | OPRM1OPRD1OPRK1HDAC1PRMT5 | |
| SCHEMBL12608179 | 0.82 | OPRM1 (0.50) | OPRM1OPRD1OPRK1HDAC1PRMT5 | |
| SCHEMBL4075715 | 0.82 | HDAC1 (0.48) | OPRM1OPRD1OPRK1HDAC1HTR1D | |
| Hydrochloric Acid SCHEMBL16194744 | 0.81 | OPRM1 (0.49) | OPRM1OPRD1OPRK1HDAC1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |