Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.47 |
| ▸ | SMO | Q99835 | 2/20 | 0.40 |
| ▸ | PAICS | P22234 | 2/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4075715 | 0.88 | HDAC1 (0.48) | HDAC1HDAC8HDAC6OPRM1OPRD1 | |
| SCHEMBL4074727 | 0.85 | OPRM1 (0.55) | HDAC1OPRM1OPRD1OPRK1PRMT5 | |
| SCHEMBL12650844 | 0.84 | HDAC1 (0.50) | HDAC1HDAC8HDAC6OPRM1OPRD1 | |
| SCHEMBL12608134 | 0.81 | OPRM1 (0.48) | HDAC1OPRM1OPRD1OPRK1PRMT5 | |
| SCHEMBL4079315 | 0.81 | OPRM1 (0.56) | HDAC1HDAC8OPRM1OPRD1OPRK1 | |
| SCHEMBL4392907 | 0.81 | OPRM1 (0.54) | HDAC1OPRM1OPRD1OPRK1PRMT5 | |
| Hydrochloric Acid SCHEMBL3339672 | 0.80 | OPRM1 (0.48) | HDAC1OPRM1OPRD1OPRK1PRMT5 | |
| Trifluoroacetic Acid SCHEMBL3339102 | 0.79 | HDAC1 (0.52) | HDAC1HDAC8HDAC6OPRM1OPRD1 | |
| SCHEMBL4072878 | 0.76 | OPRM1 (0.48) | HDAC1OPRM1OPRD1OPRK1 | |
| SCHEMBL12651388 | 0.72 | OPRM1 (0.59) | HDAC1HDAC8HDAC6OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |