Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | SFRP1 | Q8N474 | 4/20 | 0.39 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1014342 | 0.93 | HTR6 (0.46) | HTR6GPR119SFRP1 | |
| SCHEMBL1015429 | 0.87 | HTR6 (0.47) | HTR6 | |
| SCHEMBL1015807 | 0.86 | GPR119 (0.45) | HTR6GPR119SFRP1 | |
| SCHEMBL4081306 | 0.82 | TP53 (0.42) | HTR6GPR119SFRP1 | |
| SCHEMBL1015330 | 0.82 | GPR119 (0.43) | HTR6GPR119SFRP1 | |
| SCHEMBL1012382 | 0.81 | PDE4B (0.51) | HTR6GPR119SFRP1 | |
| SCHEMBL1012384 | 0.81 | PDE4B (0.51) | HTR6GPR119SFRP1 | |
| SCHEMBL1012808 | 0.81 | PDE4B (0.51) | HTR6GPR119SFRP1 | |
| SCHEMBL1013417 | 0.79 | HTR6 (0.47) | HTR6 | |
| SCHEMBL1013418 | 0.79 | HTR6 (0.47) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081890-A1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008055847-A1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |