Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 6/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1012528 | 0.93 | TP53 (0.47) | TP53POLBGPR119ALDH1A1MEN1 | |
| SCHEMBL1018293 | 0.87 | HTR6 (0.48) | HTR6 | |
| SCHEMBL1016748 | 0.82 | SFRP1 (0.47) | TP53GPR119SMN1; SMN2HTR6SFRP1 | |
| SCHEMBL4076466 | 0.82 | HTR6 (0.41) | GPR119HTR6SFRP1 | |
| SCHEMBL1015101 | 0.79 | SFRP1 (0.46) | TP53GPR119HTR6SFRP1 | |
| SCHEMBL1015103 | 0.79 | SFRP1 (0.46) | TP53GPR119HTR6SFRP1 | |
| SCHEMBL13230102 | 0.79 | TP53 (0.48) | TP53POLBGPR119ALDH1A1MEN1 | |
| SCHEMBL1016558 | 0.79 | GPR119 (0.45) | GPR119HTR6SFRP1 | |
| SCHEMBL1012808 | 0.78 | PDE4B (0.51) | GPR119ALDH1A1LMNAHTR6SFRP1 | |
| SCHEMBL1012384 | 0.78 | PDE4B (0.51) | GPR119ALDH1A1LMNAHTR6SFRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081890-A1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008055847-A1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |