Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.61 |
| ▸ | CA9 | Q16790 | 2/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | NSD2 | O96028 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.54 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | BRD2 | P25440 | 1/20 | 0.53 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28578514 | 0.88 | CA12 (0.56) | CA12CA9L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL11174344 | 0.87 | SMN1; SMN2 (0.69) | L3MBTL1POLBNSD2LMNAALDH1A1 | |
| SCHEMBL14623888 | 0.87 | CNR1 (0.58) | CA12CA9OPRK1LMNASLC12A2 | |
| SCHEMBL30681710 | 0.85 | LMNA (0.55) | CA12CA9L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL7011026 | 0.83 | TSHR (0.74) | CYP1A2CYP3A4POLBCYP2C19ALDH1A1 | |
| SCHEMBL17101701 | 0.83 | NR3C2 (0.48) | CA12CA9L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL411161 | 0.83 | SFRP1 (0.66) | L3MBTL1POLBNSD2BRD4BRD2 | |
| SCHEMBL20100265 | 0.82 | TSHR (0.54) | L3MBTL1POLBALDH1A1 | |
| SCHEMBL1032718 | 0.81 | KDM4E (0.60) | CA12CA9L3MBTL1CYP1A2CYP3A4 | |
| SCHEMBL28113718 | 0.81 | POLB (0.56) | CA12CA9L3MBTL1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112047865-B | Method for synthesizing N-alkyl sulfonamide in water | 南京理工大学 | 2022-12-02 | — | — | CN | disclosed |
| CN-110832034-B | Moisture-curable resin composition, adhesive for electronic component, and adhesive for display element | 积水化学工业株式会社 | 2022-10-18 | — | — | CN | disclosed |
| US-11124482-B2 | C-met modulators and methods of use | EXELIXIS, INC. (US) | 2021-09-21 | — | — | US | disclosed |
| US-20210253530-A9 | C-MET MODULATORS AND METHODS OF USE | EXELIXIS, INC. | 2021-08-19 | — | — | US | disclosed |
| CN-112047865-A | Method for synthesizing N-alkyl sulfonamide in water | 南京理工大学 | 2020-12-08 | — | — | CN | disclosed |
| US-20200331860-A1 | C-Met Modulators and Methods of Use | EXELIXIS INC (US) | 2020-10-22 | — | — | US | disclosed |
| CN-110832034-A | Moisture-curable resin composition, adhesive for electronic component, and adhesive for display element | 积水化学工业株式会社 | 2020-02-21 | — | — | CN | disclosed |
| US-20170355678-A1 | C-Met Modulators and Methods of Use | EXELIXIS INC (US) | 2017-12-14 | — | — | US | disclosed |
| US-20160185725-A1 | c-Met Modulators and Method of Use | EXELIXIS, INC. | 2016-06-30 | — | — | US | disclosed |
| CN-104418678-B | A kind of method of synthetic N-alkyl sulfonamide derivatives | NANJING UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2016-05-18 | — | — | CN | disclosed |
| US-8178532-B2 | c-Met modulators and method of use | EXELIXIS, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20120022065-A1 | C-Met Modulators and Method of Use | EXELIXIS, INC. (US) | 2012-01-26 | — | — | US | disclosed |
| US-8067436-B2 | N-(4-{[7-{[3-(diethylamino)propyl] oxy}-6-(methyloxy) quinazolin-4-yl]oxy}-3- fluorophenyl)-N'-(4- fluorophenyl) cyclopropane-1,1-dicarboxamide; for modulating protein kinase enzymatic activity for modulating cell activities such as proliferation, differentiation, programmed cell death | EXELIXIS, INC. (US) | 2011-11-29 | — | — | US | disclosed |
| US-20110077233-A1 | C-Met Modulators and Method of Use | EXELIXIS, INC. (US) | 2011-03-31 | — | — | US | disclosed |
| US-7579473-B2 | N-(4-{[7-{[3-(diethylamino)propyl] oxy}-6-(methyloxy) quinazolin-4-yl]oxy}-3- fluorophenyl)-N'-(4- fluorophenyl) cyclopropane-1,1-dicarboxamide; for modulating protein kinase enzymatic activity for modulating cell activities such as proliferation, differentiation, programmed cell death | EXELIXIS, INC. (US) | 2009-08-25 | — | — | US | disclosed |
| US-20090170896-A1 | c-Met modulators and methods of use | EXELIXIS, INC. (US) | 2009-07-02 | — | — | US | disclosed |
| US-20090105299-A1 | c-MET MODULATORS AND METHODS OF USE | EXELIXIS, INC (US) | 2009-04-23 | — | — | US | disclosed |
| US-20070244116-A1 | c-MET MODULATORS AND METHOD OF USE | EXELIXIS, INC. (US) | 2007-10-18 | — | — | US | disclosed |
| US-20070225307-A1 | C-MET MODULATORS AND METHOD OF USE | EXELIXIS, INC. (US) | 2007-09-27 | — | — | US | disclosed |
| US-20070054928-A1 | c-Met modulators and methods of use | EXELIXIS, INC. (US) | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200331860-A1 | C-Met Modulators and Methods of Use | FLT4, FLT1, MET | CA12 2958/4885CA9 1962/4885L3MBTL1 2294/4885 |
| US-20070054928-A1 | c-Met modulators and methods of use | FLT4, FLT1, MET | CA12 2958/4885CA9 1962/4885L3MBTL1 2294/4885 |
| US-20120022065-A1 | C-Met Modulators and Method of Use | FLT4, MET, FLT1 | CA12 2755/4885CA9 2229/4885L3MBTL1 2747/4885 |
| US-20170355678-A1 | C-Met Modulators and Methods of Use | FLT4, FLT1, MET | CA12 2958/4885CA9 1962/4885L3MBTL1 2294/4885 |
| US-20210253530-A9 | C-MET MODULATORS AND METHODS OF USE | FLT4, FLT1, MET | CA12 2958/4885CA9 1962/4885L3MBTL1 2294/4885 |
| US-20090170896-A1 | c-Met modulators and methods of use | FLT4, MET, FLT1 | CA12 2747/4885CA9 2270/4885L3MBTL1 2564/4885 |
| US-20070225307-A1 | C-MET MODULATORS AND METHOD OF USE | FLT4, MET, FLT1 | CA12 2755/4885CA9 2229/4885L3MBTL1 2747/4885 |
| US-20160185725-A1 | c-Met Modulators and Method of Use | FLT4, MET, FLT1 | CA12 2755/4885CA9 2229/4885L3MBTL1 2747/4885 |
| US-20070244116-A1 | c-MET MODULATORS AND METHOD OF USE | FLT4, MET, FLT1 | CA12 2755/4885CA9 2229/4885L3MBTL1 2747/4885 |
| US-11124482-B2 | C-met modulators and methods of use | FLT4, FLT1, MET | CA12 2958/4885CA9 1962/4885L3MBTL1 2294/4885 |
| US-20090105299-A1 | c-MET MODULATORS AND METHODS OF USE | FLT4, MET, FLT1 | CA12 2747/4885CA9 2270/4885L3MBTL1 2564/4885 |
| US-20110077233-A1 | C-Met Modulators and Method of Use | FLT4, MET, FLT1 | CA12 2755/4885CA9 2229/4885L3MBTL1 2747/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.