Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.42 |
| ▸ | PHGDH | O43175 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4070072 | 1.00 | CNR2 (0.45) | CNR2RIPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL27813795 | 1.00 | CNR2 (0.45) | CNR2RIPK1HDAC3HDAC4HDAC1 | |
| SCHEMBL4075272 | 0.86 | CNR2 (0.43) | CNR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5662464 | 0.86 | CNR2 (0.43) | CNR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL18170175 | 0.84 | SLC6A9 (0.56) | KDM4EALDH1A1HTTMEN1KMT2A | |
| SCHEMBL22805483 | 0.84 | CNR2 (0.44) | CNR2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL25295633 | 0.83 | LMNA (0.51) | CNR2RIPK1ALDH1A1GPR88MEN1 | |
| SCHEMBL25353842 | 0.83 | RIPK1 (0.45) | RIPK1GPR88EPHX2MAPK13ROCK2 | |
| SCHEMBL21839155 | 0.83 | RIPK1 (0.45) | RIPK1GPR88EPHX2MAPK13ROCK2 | |
| SCHEMBL25295634 | 0.83 | LMNA (0.51) | CNR2RIPK1ALDH1A1GPR88MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |
| EP-1686999-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | AstraZeneca AB (SE) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005049033-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSYNE KINASES | ASTRAZENECA AB (SE) | 2005-06-02 | — | — | WO | disclosed |