Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 10/20 | 0.44 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.43 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078393 | 0.83 | ALDH1A1 (0.44) | MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL7175076 | 0.78 | CYP1A2 (0.42) | EGLN1PTPN7MEN1KMT2AKDM4E | |
| Water SCHEMBL6036774 | 0.77 | CYP1A2 (0.41) | EGLN1PTPN7MEN1KMT2AKDM4E | |
| SCHEMBL8779339 | 0.76 | EGLN2 (0.45) | EGLN1FTOMEN1KMT2AEPHX1 | |
| SCHEMBL6567209 | 0.75 | KDM4C (0.58) | EGLN1KDM4CMEN1KMT2AKDM4E | |
| SCHEMBL1208104 | 0.75 | EGLN1 (0.62) | EGLN1EGLN3FTOKDM4C | |
| SCHEMBL1833771 | 0.74 | HSD17B10 (0.58) | ALDH1A1EPHX1 | |
| SCHEMBL13284331 | 0.74 | EGLN1 (0.53) | EGLN1EGLN3FTOPTPN7KDM4C | |
| SCHEMBL30636265 | 0.73 | PLAU (0.46) | EGLN1PTPN7MEN1KMT2AKDM4E | |
| SCHEMBL4073461 | 0.73 | PLAU (0.46) | EGLN1PTPN7MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1538160-B1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2009-06-03 | — | — | EP | disclosed |
| EP-0911340-B1 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | FIBROGEN INC (US) | 2005-07-06 | — | — | EP | disclosed |
| EP-1538160-A1 | Substituted Isoquinolin-3-carboxyamides, their preparation and medical use | FIBROGEN, INC. (US) | 2005-06-08 | — | — | EP | disclosed |
| EP-0911340-A2 | Substituted Isoquinolin-3-Carboxyamides, their preparation and medical use | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-04-28 | — | — | EP | disclosed |