Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | PRNP | P04156 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MGAM | O43451 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4303922 | 0.87 | NCEH1 (0.54) | KDM4CKMT2AMEN1EGLN1L3MBTL1 | |
| SCHEMBL6603947 | 0.80 | KDM4C (0.56) | KDM4CKMT2AMEN1PRNPRXFP1 | |
| SCHEMBL4864823 | 0.78 | ALDH1A1 (0.54) | KDM4CKMT2AMEN1KDM4EMGAM | |
| SCHEMBL294784 | 0.77 | MGAM (0.53) | KDM4CKMT2AMEN1PRNPRXFP1 | |
| SCHEMBL1495919 | 0.76 | MEN1 (0.66) | KDM4CKMT2AMEN1PRNPRXFP1 | |
| Benzene SCHEMBL6364361 | 0.76 | MEN1 (0.66) | KDM4CKMT2AMEN1PRNPRXFP1 | |
| SCHEMBL6563671 | 0.76 | KDM4C (0.48) | KDM4CKMT2AMEN1PRNPRXFP1 | |
| SCHEMBL4076740 | 0.75 | EGLN1 (0.44) | KDM4CKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL10443450 | 0.75 | ALDH1A1 (0.56) | KDM4CKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL8779339 | 0.74 | EGLN2 (0.45) | KMT2AMEN1GAAHPGDEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765871-B1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | FIBROGEN INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0765871-A1 | Substituted Quinoline-2-carboxamides, their preparation and their use as prolyle-4-hydroxylase Inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-04-02 | — | — | EP | disclosed |