Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.84 |
| ▸ | HPGD | P15428 | 5/20 | 0.73 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | MAPT | P10636 | 2/20 | 0.73 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9070025 | 0.92 | L3MBTL1 (1.00) | L3MBTL1HPGDMAPK10ALDH1A1KDM4E | |
| SCHEMBL12132468 | 0.86 | L3MBTL1 (0.70) | L3MBTL1HPGDMAPK10ALDH1A1KDM4E | |
| SCHEMBL4515370 | 0.86 | KMT2A (0.71) | L3MBTL1HPGDMAPK10ALDH1A1KDM4E | |
| SCHEMBL10179557 | 0.85 | L3MBTL1 (0.69) | L3MBTL1HPGDMAPK10ALDH1A1KDM4E | |
| SCHEMBL14104417 | 0.85 | HPGD (0.79) | L3MBTL1HPGDMAPK10ALDH1A1KDM4E | |
| SCHEMBL6170359 | 0.82 | HPGD (0.75) | L3MBTL1HPGDMAPK10ALDH1A1KDM4E | |
| SCHEMBL14104161 | 0.81 | HPGD (0.73) | L3MBTL1HPGDMAPK10ALDH1A1KDM4E | |
| SCHEMBL890758 | 0.81 | POLB (1.00) | L3MBTL1HPGDMAPK10ALDH1A1KDM4E | |
| SCHEMBL25207565 | 0.81 | MAPK10 (1.00) | L3MBTL1HPGDMAPK10ALDH1A1KDM4E | |
| SCHEMBL7377084 | 0.80 | ALDH1A1 (0.71) | L3MBTL1HPGDMAPK10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325933-A1 | Pyrimidinone Derivatives and Their Use as a Drug | IPSEN PHARMA S.A.S. (FR) | 2009-12-31 | — | — | US | disclosed |
| EP-2054419-A2 | PYRIMIDINONE DERIVATIVES AND THEIR USE AS A DRUG | Societe de Conseils de Recherches et d'Applications Scientifique (FR) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008012413-A2 | PYRIMIDINONE DERIVATIVES AND THEIR USE AS A DRUG | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUE (S.C.R.A.S.) (FR) | 2008-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325933-A1 | Pyrimidinone Derivatives and Their Use as a Drug | CNR1, CNR2, GPR18 | L3MBTL1 4857/4885HPGD 449/4885MAPK10 2812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.